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Fragile sites in human chromosomes I The effect of methionine on the Xq fragile site |
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| Authors: | Patricia N. Howard-Peebles Johnny C. Pryor |
| Affiliation: | Institute of Genetics/Department of Microbiology, University of Southern Mississippi, Hattiesburg, and Ellisville State School, Ellisville;Honors College, University of Southern Mississippi, Hattiesburg, U.S.A. |
| Abstract: | The Xq fragile site found in males having non-specific X-linked mental retardation was studied by varying the chemical and physical parameters of leukocyte cultures. Methionine was shown to be required for marker expression in both medium 199 and MEM. Banding studies indicated that methionine does not function as a stabilizing factor for the fragile site on Xq. |
| Keywords: | Fragile sites fragile Xq human chromosomes marker X Xq fragile site X-linked MR |