新生儿窒息后心率变异性研究

目的 探讨新生儿窒息后心率变异性的改变及其临床意义.方法 应用美国Compas XMHolter分析系统检测22例窒息新生儿和21例正常新生儿的心率变异性.结果 新生儿窒息后早期及恢复期24小时窦性RR间期标准差(SDNN)、每5分钟窦性RR间期标准差的均值(SDNNIDX)、心率变异性指数(HRVI)与对照组比较显著降低(P<0.05).SDNN、SDNNIDX、HRVI与24小时最慢心率呈负相关(r:0.43～0.57,P<0.01),SDNNIDX与24小时最快心率呈正相关(γ: 29,P <0.05).结论 新生儿窒息后心脏自主神经功能受损并影响心率的改变.心率变异性参数是判断新生儿窒息后心肌损害较稳定的指标.

Study of Heart Rate Variability in Neonatal Aspyhxia

ve To investigate the changes of heart rate variability (HRV) after asphyxia of the newborn and its clinical significance. Methods Used HRV time domain analysis method of Compas XM Holter system to study 22 newborns with asphyxia and 21 normal. Results RR(SDNN) ,HRV index (HRVI), mean of the standard deviation of all RR for each 5 - minute segments for all sessions (SDNNIDX) singnificantly decreased in the early and restoration stages after asphyxia of the newborn compared with those in control group (P < 0. 05). There were moderate negative correlations between SDNN, SDNNIDX, HRVI and minimum heart rate of 24 hours( r: 0. 43 - 0. 57, P< 0. 01). There was mild positive correlations between SDNNIDX and maximum heart rate of 24 hours (r - 0. 29 P<0. 05). Conclusions The function of cardiac autonomic nevous systems was decreased in the newborn with asphyxia. Heart rate changes after asphyxia of the newborn were relation to the decreased autonomic nevous function. The parameteres of HRV can be used as indexes to judge the myocardium involved after asphyxia of the newborn.