| 益母草碱对大鼠急性心肌缺血损伤心肌肌钙蛋白T的影响 |
| |
| 引用本文： | 熊莺,杨解人. 益母草碱对大鼠急性心肌缺血损伤心肌肌钙蛋白T的影响[J]. 中国实验方剂学杂志, 2007, 13(2): 21-24 |
| |
| 作者姓名： | 熊莺 杨解人 |
| |
| 作者单位： | 皖南医学院药理教研室,安徽,芜湖,241001 |
| |
| 基金项目： | 安徽省教育厅自然科学基金项目（2003kj322） |
| |
| 摘 要： | 目的：观察益母草碱（Leo）对大鼠急性心肌缺血损伤心肌肌钙蛋白T（cTnT）水平的保护作用。方法：采用垂体后叶素（Pit）腹腔注射法诱导大鼠急性心肌缺血，以J点（△mv）和T波（△mv）上移幅度评价急性心肌缺血程度；采用放免法检测血清及心肌cTnT的含量。结果：益母草碱（3，5，7，9mg／kg）可防止Pit诱导急性心肌缺血J点及T波的抬高，并能降低血清和心肌cTnT含量（P〈0．05或P〈0．01），在一定剂量范围内存在量效关系。结论：Leo具有对抗垂体后叶素性急性心肌缺血损伤的作用。
|
| 关 键 词： | 益母草碱 垂体后叶素 心肌缺血 心肌肌钙蛋白T |
| 文章编号： | 1005-9903（2007）02-0021-04 |
| 收稿时间： | 2006-02-07 |
| 修稿时间： | 2006-02-07 |
Protective Effect of Leonurine on Acute Myocardial Ischemia Injury in Rats |
| |
| XIONG Ying,YANG Jie-ren. Protective Effect of Leonurine on Acute Myocardial Ischemia Injury in Rats[J]. China Journal of Experimental Traditional Medical Formulae, 2007, 13(2): 21-24 |
| |
| Authors: | XIONG Ying YANG Jie-ren |
| |
| Affiliation: | Wannan Medical College, Wuhu 241001, China |
| |
| Abstract: | Objective:To investigate the protective effect of leonurine(Leo) on pituitrin(Pit)-induced acute myocardial ischemia injury in rats.Methods:Pit was administrated intraperitoneally to induce acute myocardial ischemia injury in rats.The locomotion of J point(mv) and T wave(mv) in ECG was allowed to evaluate the degree of myocardial ischemia.The content of cardiac troponin T(cTnT) in serum and myocardium was measured by radio immunoassay.Results:In Leo(3,5,7,9 mg/kg) groups,the elevation of J point and T wave was lowered.The contents of cTnT in serum and myocardium were obviously decreased.Linear regression analysis(scatterplot) indicated that there is dose-effect relationship within certain dose range.Conclusions:Leo can inhibit Pit-induced myocardial ischemia injury,with dose-dependent effect. |
| |
| Keywords: | Leonurine Pituitrin Myocardial ischemia Cardiac troponin T |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 |
|
点击此处可从《中国实验方剂学杂志》下载全文 |
