| 正常组织和瘢痕组织中黑色素细胞超微结构的对比研究 |
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| 引用本文： | 张琳西,郭树忠,王臻,马显杰,黄梅. 正常组织和瘢痕组织中黑色素细胞超微结构的对比研究[J]. 医学争鸣, 2002, 23(18): 1713-1715 |
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| 作者姓名： | 张琳西 郭树忠 王臻 马显杰 黄梅 |
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| 作者单位： | 1. 第四军医大学,西京医院整形外科中心,陕西,西安,710033
2. 第四军医大学,基础部中心实验室,陕西,西安,710033 |
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| 基金项目： | 教育部 1997年留学回国人员启动基金资助 |
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| 摘 要： | 目的：观察正常组织和瘢痕组织中黑色素细胞超微结构的区别，探讨在烧（创）伤后黑色素细胞在瘢痕形成过程中的作用。方法：用JEM2000－EX型透射电子显微镜观察正常组织和瘢痕组织细胞的超微结构。结果：透射电镜下可见瘢痕组织中黑色素细胞有较多的黑素小体，基底层细胞多为黑色素细胞，而且角质细胞内有大量的黑素颗粒。正常组织中基底层黑色素细胞较少，且角质细胞嗜取的黑素颗粒也较少。透射电镜下培养的瘢痕黑素细胞内有大量的2－3期黑素小体，而正常黑色素细胞的黑素颗粒较少。其它细胞器结构两者无明显差别。结论：烧（创）伤后，黑色素细胞生存的微环境发生改变，引起黑色素细胞增生、迁移、大量分泌黑素，促进瘢痕形成及皮肤色素沉着。
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| 关 键 词： | 对比研究 黑素细胞 超微结构 肥大性瘢痕 |
| 文章编号： | 1000-2790(2002)18-1713-03 |
| 修稿时间： | 2002-04-10 |
Contrast study on the ultrastructure of melanocytes derived from normal tissue and hypertrophic scar |
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| ZHANG Lin-Xi ,GUO Shu-Zhong ,WANG Zhen ,MA Xian-Jie ,HUANG Mei Center of Plastic Surgery,Xijing Hospital,Preclinical Experiment Center,Faculty of Preclinical Medicine,Fourth Military Medical University,Xi'an ,China. Contrast study on the ultrastructure of melanocytes derived from normal tissue and hypertrophic scar[J]. Negative, 2002, 23(18): 1713-1715 |
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| Authors: | ZHANG Lin-Xi GUO Shu-Zhong WANG Zhen MA Xian-Jie HUANG Mei Center of Plastic Surgery Xijing Hospital Preclinical Experiment Center Faculty of Preclinical Medicine Fourth Military Medical University Xi'an China |
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| Affiliation: | ZHANG Lin-Xi 1,GUO Shu-Zhong 1,WANG Zhen 1,MA Xian-Jie 1,HUANG Mei 2 1Center of Plastic Surgery,Xijing Hospital,2Preclinical Experiment Center,Faculty of Preclinical Medicine,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | AIM To investigate the effects of melanocytes on the hypertrophic scars. METHODS We employed transmission microscope to observe the ultrastructure of melanocytes derived from normal tissues and hypertrophic scars. RE-SULTS We found that, in hypertrophic scars, there was much more melanosome in melanocytes, most of which was located in the basal cell layer and a great amount of melanin in keratinocytes. But in the normal tissue, melanocytes and melanin were much less. CONCLUSION Melanocyte contributes to the formation of scars and pigmentation. |
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| Keywords: | melanocytes/ultrastructure cicatrix hypertrophic |
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