Effects of psychosocial functioning,depression, seizure frequency,and employment on quality of life in patients with epilepsy |
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| Institution: | 1. Department for Epilepsy and Clinical Neurophysiology, Institute of Mental Health, Palmotićeva 37, 11000 Belgrade, Serbia;2. Belgrade University Medical School, Dr Subotića 8, 11000 Belgrade, Serbia;3. Faculty of Philosophy, Department for Psychology — Statistics, University of Belgrade, Čika Ljubina 18-20, 11000 Belgrade, Serbia;1. Institute of Child Health, Clinical Center of Montenegro, Podgorica, Montenegro;2. Faculty of Medicine, University of Montenegro, Podgorica, Montenegro;3. Neurology Clinic, Clinical Center of Vojvodina, Novi Sad, Serbia;4. Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia;5. Clinic of Anesthesia and Intensive Therapy, Clinical Centre of Vojvodina, Novi Sad, Serbia;6. Neurology Clinic, Clinical Center of Montenegro, Podgorica, Montenegro;1. Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA;2. Department of Pediatric Neurology, Arkansas Children Hospital, Little Rock, AR, USA;3. Department of Community Medicine, Dr. RP Government Medical College, Tanda, India;4. Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA;5. Department of Neurology, Ohio State University Wexner Medical Center, Columbus, OH, USA |
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| Abstract: | This study aimed to investigate the quality of life (QOL) in patients with epilepsy and its correlation with psychosocial impact, depression, seizure-related items, and living circumstances. One hundred two patients who visited the epilepsy clinic at Nagoya City University Hospital participated in this study. We used the Quality of Life in Epilepsy Inventory-31-P (QOLIE-31-P) as a measure of QOL, the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) as the screening instrument for rapid detection of major depression, and the Side Effects and Life Satisfaction Inventory (SEALS) to evaluate psychosocial functioning, seizure-related items, and living circumstances. Significant correlations of the QOLIE-31-P overall score with these questionnaires and seizure-related or demographic variables were identified and analyzed by stepwise linear regression. The QOLIE-31-P overall score correlated significantly with the NDDI-E, SEALS overall score, number of anticonvulsants, frequency of focal seizure with impairment of consciousness or awareness (focal seizure), sheltered work, and employment. The stepwise linear regression showed that the QOLIE-31-P overall score was explained by the effects of psychosocial functioning, depression, frequency of focal seizure, and employment, in that order, with these factors explaining 74% of the variance. Thus, using both the SEALS and NDDI-E may be useful to detect some aspects of QOL in clinical settings. |
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