Effects of seizure severity and seizure freedom on the health-related quality of life of an African population of people with epilepsy |
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| Institution: | 1. Neurology Unit, Medicine Department, Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria;2. Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria;2. Department of Physical Therapy, University of British Columbia, Vancouver, Canada;3. Department of Medicine (Neurology), Sunnybrook HSC, University of Toronto, and Sunnybrook Research Institute, Toronto, Canada;4. Pacific University, Oregon;1. Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea;2. Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, CA;3. Epilepsy Center, Lurie Children''s Hospital, Chicago, IL;4. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL;1. Cleveland Clinic Sleep Disorders Center, Neurological Institute, Cleveland, OH, United States;2. Cleveland Clinic Epilepsy Center, Neurological Institute, Cleveland, OH, United States;3. Cleveland Clinic Quantitative Health Sciences, Cleveland, OH, United States;4. Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, United States;1. Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea;2. Department of Pediatrics, Korea University College of Medicine, Seoul, Republic of Korea;3. Division of Pediatric Neurology, Pediatric Epilepsy Clinic, Severance Children''s Hospital, Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea;4. Department of Pediatrics, Pusan National University Children''s Hospital School of Medicine, Yangsan, Republic of Korea;5. Department of Pediatrics, Chonbuk National University, Medical School, Jeonju, Republic of Korea;6. Department of Pediatrics, National Health Insurance Corporation, Ilsan Hospital, Goyang, Republic of Korea;7. Department of Pediatrics, Kyungpook National University College of Medicine, Daegu, Republic of Korea;8. Department of Pediatrics, Gangnam Severance Hospital, Younsei University College of Medicine, Seoul, Republic of Korea;9. Department of Pediatrics, Inje University College of Medicine, Goyang, Republic of Korea;10. Department of Psychology, Yonsei University, Seoul, Republic of Korea;1. Izmir University of Economics, Department of Psychology, Izmir 35330, Turkey;2. Dokuz Eylül University, School of Medicine, Department of Neurology, Izmir, Turkey |
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| Abstract: | PurposeThis study aimed at determining the effects of seizure severity and seizure freedom on health-related quality of life (HRQOL) of people with epilepsy (PWE) in the presence of perceived stigma in a sub-Saharan African culture.MethodsHealth-related quality of life was assessed using QOLIE-31 in 93 consecutive adults (56 males and 37 females) with epilepsy. They were stratified into seizure-free, low–moderate seizure severity, and high seizure severity groups based on the seizure type and the number of seizures in the previous 6 months. Other illness variables and sociodemographic variables were also obtained. A 3-item perceived stigma scale was administered. A modified QOLIE-31 (excluding the epilepsy-specific items) was given to 102 age- and sex-matched healthy controls.ResultsThere was moderate negative correlation between seizure severity and mean total HRQOL score as well as scores on the Seizure Worry (p = .000), Overall Quality of Life (p = .000), and Social Function (p = .001) subscales of QOLIE-31. Overall, the healthy control subjects had a higher mean HRQOL score compared with the PWE put together (71.0 + 11.1 vs 64.2 ± 13.6, p = .001). However, there was no difference in the mean HRQOL score between the seizure-free individuals and the healthy controls (p = .270). Seizure severity was associated with HRQOL independent of perceived stigma on a multiple regression analysis.ConclusionThis study provides evidence that seizure severity relates to health-related quality of life in an inverse, graded manner and independent of perceived stigma. Seizure-free people with epilepsy can have quality of life comparable with healthy individuals. |
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