Gelastic epilepsy without hypothalamic hamartoma: Three additional cases |
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| Institution: | 1. Department of Pediatrics, Pavia University Fondazione, IRCCS Policlinico San Matteo, Pavia, Italy;2. Paediatric and Child Neurology Unit, Cava de'' Tirreni AOU S. Giovanni di Dio e Ruggiero d''Aragona Hospital, Salerno, Italy;3. NESMOS Department, Chair of Neuroradiology, Faculty of Medicine & Psychology, La Sapienza University, c/o Sant'' Andrea Hospital, Rome, Italy;4. NESMOS Department, Child Neurology, Chair of Pediatrics, Faculty of Medicine & Psychology, Sant'' Andrea Hospital, La Sapienza University, Rome, Italy;1. Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children''s Hospital, Boston, MA, USA;2. Department of Child Neurology, Hospital Sant Joan de Déu, Universidad de Barcelona, Barcelona, Spain;3. Department of Neurology, Boston University School of Medicine, Boston, MA, USA;4. Department of Sleep Medicine, CGH Medical Center, Sterling, IL, USA;5. Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY, USA;6. Department of Internal Medicine, Carney Hospital, Dorchester, MA, USA;1. Department of Pediatric Surgery, Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA;2. Department of Surgery, Denver Health Medical Center, Denver, CO, USA;3. Department of Pediatric Surgery, Cardinal Glennon Children’s Medical Center, St. Louis, MO 63104, USA |
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| Abstract: | We describe three children with gelastic seizures without hypothalamic hamartoma whose seizures were characterized by typical laughing attacks associated or not with other seizure types. Ictal/interictal EEG and magnetic resonance imaging were performed. All three subjects showed a good response to carbamazepine therapy with complete seizure control in addition to a benign clinical and cognitive outcome. These three cases confirm that gelastic epilepsy without hypothalamic hamartoma, both in cryptogenic or symptomatic patients (one child showed a dysplastic right parietotemporal lesion), usually has a more benign natural history, and carbamazepine seems to be the most efficacious therapy to obtain both immediate and long-term seizure control. These findings need to be confirmed in a larger sample of children affected by gelastic epilepsy without hypothalamic hamartoma. |
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