A systematic review of genetic diversity of human rotavirus circulating in South Korea |
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| Institution: | 1. Department of Microbiology, National Autonomous University of León, Nicaragua (UNAN-León), Nicaragua;2. Division of Molecular Virology, Clinical and Experimental Medicine, Medical Faculty University of Linköping, 581 85 Linköping, Sweden;1. Animal Health Science Directorate, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON, K1A 0Y9, Canada;2. Department of Health Management, University of Prince Edward Island, Atlantic Veterinary College, 550 University Avenue, Charlottetown, PEI, C1A 4P3, Canada;3. USDA APHIS VS Centers for Epidemiology and Animal Health, Surveillance Design and Analysis, 2150 Centre Ave, Fort Collins, CO, 80526-8117, United States;4. Animal Health Directorate, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON, K1A 0Y9, Canada;5. GIS Gas Infusion Systems Inc., 40 Dante Road, St. Andrews, New Brunswick, E5V 3B9, Canada;1. National Institute of Cholera and Enteric Diseases, Kolkata, India;2. Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan;1. Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary;2. Department of Medical Microbiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary;3. Department of Veterinary Medicine, University of Bari “Aldo Moro”, Bari, Italy;4. Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA |
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| Abstract: | Rotavirus infections continue to be the leading cause of severe diarrhea in young Korean children. Rotavirus data acquired from uninterrupted surveillance studies between 1989 and 2009 in South Korea were analyzed to better understand the genetic diversity and evolution. The relationship between rotaviruses and the currently licensed rotavirus vaccine viruses was also examined. The most prevalent rotavirus strains, with genotype G1P8], followed by G3P8], G4P6], and G2P4], accounted for approximately 76.7% of the total identified strains, and more recently, rotavirus G9P8] has significance increased to be the fifth most common genotype. Phylogenetic analyses underscored the heterogeneity between viral populations within each genotype, with different lineages and sub-lineages. Although the currently licensed rotavirus vaccines are effective, safe, and economical, additional data from rotavirus monitoring is necessary to evaluate the efficacy of these vaccines for their sustained use in South Korea. The present study provides comprehensive and up-to-date information regarding the epidemiology, genetic diversity, and evolution of the circulating rotaviruses in South Korea. |
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| Keywords: | Genetic diversity Evolution Rotavirus Vaccine program South Korea |
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