结直肠癌肝转移患者生存情况及预后因素分析

目的 探讨结直肠癌肝转移患者的生存情况及其预后相关因素.方法 采用Kaplan-Meier和多因素回归分析方法,分析112例有完整随访资料的结直肠癌肝转移患者的生存情况及影响预后的相关因素.结果 112例患者的中位生存时间为18.3个月,1、2、3和5年生存率分别为60.8%、35.0%、20.3%和4.8%.单因素分析显示,患者性别、年龄、原发肿瘤部位、化疗与否、肿瘤的病理类型与患者的总生存时间无关(P＞0.05),而原发肿瘤治疗方法、肝脏转移时间、原发肿瘤大体类型、肝脏转移灶手术与否和临床分期与患者的预后有关(P＜0.05).多因素回归分析显示,肝脏转移灶手术与否、原发肿瘤大体类型和临床分期是影响结直肠癌肝转移患者预后的主要因素(P＜0.05).结论 对于结直肠癌肝转移的患者应积极切除肝转移病灶,延长患者生存时间.

Survival status and prognostic factors of liver metastases from colorectal cancer

Objective To analyze the survival status and prognostic factors of patients with liver metastases from colorectal cancer.Methods The survival rate and prognostic factors of 112 patients with liver metastases from colorectal cancer,who had complete follow-up data,were retrospectively assessed by Kaplan-Meier analysis and multivariate regression analysis.Results The median survival time of the 112 patients was 18.25 months.The 1-,2-,3-and 5-year overall survival rates were 60.8%,35.0%,20.3% and 4.8%,respectively.Univariate analysis demonstrated that gender,age,primary tumor site,chemotherapy and pathological types had no significant correlation with the overall survival.But the treatment of primary tumor,time of liver metastasis,gross type of tumor,resection of liver metastases and clinical stage status were all independently related with the prognosis of patients.Multivariate regression analysis showed that resection of liver metastases,gross type of tumor and clinical stage were key factors affecting the prognosis of patients with liver metastases from colorectal cancer.Conclusion Patients with advanced stage,infiltrative gross type of colorectal cancer should be followed-up closely so that liver metastases from the cancer can be diagnosed and treated early.Resection of both the primary tumor and liver metastasis may improve survival of the patients.