| Abstract: | The system of mononuclear phagocytes of the liver was blocked in male Wistar rats weighing 140–160 g by iron carbonyl (brand R-100 F) with a particle size of 1–1.5  . The blockade was carried out 2 h before partial hepatectomy and also 3 and 18 h after the operation. Injection of the iron compound before the operation and in the early prereplicative period of regeneration led to substantial delay of the peak of the index of labeled nuclei and mitotic index of the hepatocytes accompanied by a general reduction in proliferative power of the hepatocytes. Blockade of the system of mononuclear phagocytes in the period of intensive DNA synthesis by hepatocytes of the regenerating liver was less effective. The facts are evidence of the important role of the Kupffer cells in regulation of reparative regeneration of the liver.Laboratory of Pathophysiology, Department of General Pathology, Institute of Clinical and Experimental Medicine, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirk. (Presented by Academician of the Academy of Medical Sciences of the USSR V. P. Kaznacheev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 11, pp. 616–618, November, 1977. |
