| 基质金属蛋白酶及其抑制剂与眼部疾病 |
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| 引用本文： | 王静波,惠延年. 基质金属蛋白酶及其抑制剂与眼部疾病[J]. 眼科新进展, 2005, 25(1): 79-82 |
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| 作者姓名： | 王静波 惠延年 |
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| 作者单位： | 710032,陕西省西安市,第四军医大学西京医院眼科 |
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| 摘 要： | 基质金属蛋白酶(MMPs)是一组锌离子依赖性内肽酶，其主要功能是降解细胞外基质，在细胞迁移、组织重建和修复等病理生理过程中发挥作用。MMPs的蛋白水解活性主要靠与其抑制剂TIMPs之间的平衡来调节。尽管MMPs和TIMPs参与的具体机理尚未明确，但对于寻找角膜炎、白内障、青光眼及增生性玻璃体视网膜病变等眼病的发病机理有重要意义。本文综述了MMPs、TIMPs在眼病中的表达变化及作用。
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| 关 键 词： | 基质金属蛋白酶 基质金属蛋白酶抑制剂 眼病 |
| 文章编号： | 1003-5141(2005)01-0079-04 |
| 修稿时间： | 2003-07-28 |
Matrix metalloproteinase and its specific tissue inhibitors in eye diseases |
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| WANG Jing-Bo,HUI Yan-NianFrom the. Matrix metalloproteinase and its specific tissue inhibitors in eye diseases[J]. Recent Advances in Ophthalmology, 2005, 25(1): 79-82 |
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| Authors: | WANG Jing-Bo HUI Yan-NianFrom the |
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| Affiliation: | WANG Jing-Bo,HUI Yan-NianFrom the Department of Ophthalmology,Xijing Hospital of the Fourth Military Medical University,Xi'an 710032,Shaanxi Province,China |
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| Abstract: | Matrix metalloproteinses (MMPs) are a pivotal family of zinc enzymes responsible for degradation of the extracellular matrix (ECM) components, during cell migration, normal remodeling and repair processes. The potent proteolytic activities of MMPs are mainly regulated by the balance with specific tissue inhibitors of MMPs(TIMPs). Although the precise mechanisms are unknown, the contributions of MMPs and TIMPs are worth investigating in seeking the pathogenesis of various eye diseases such as keritis, cataract, glaucoma, proliferative vitreo-retinopathy, etc. In this review, the main focus is on the expressions and the contributions of MMPs and TIMPs in the eye diseases. |
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| Keywords: | matrix metalloproteinases tissue inhibitors of matrix metalloproteinases eye diseases |
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