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盐酸氨基葡萄糖联合非类固醇类抗炎药治疗小关节退变伴下腰痛
引用本文:石锐,刘浩,胡韬,丁琛.盐酸氨基葡萄糖联合非类固醇类抗炎药治疗小关节退变伴下腰痛[J].中国组织工程研究与临床康复,2011,15(26).
作者姓名:石锐  刘浩  胡韬  丁琛
作者单位:1. 四川大学华西医院,骨科,四成都市,610041;四川大学华西医院,科技发展中心,四成都市,610041
2. 四川大学华西医院,骨科,四成都市,610041
摘    要:背景:盐酸葡萄糖胺对骨关节炎的治疗作用在膝关节已经得到证实,然而盐酸氨基葡萄糖与非类固醇类抗炎药物联用的治疗腰背痛鲜有报道。目的:探讨盐酸氨基葡萄糖与小剂量非类固醇类抗炎药物联用治疗腰椎小关节退变伴下腰痛的临床效果。方法:纳入35例小关节退变伴下腰痛患者,给予口服盐酸氨基葡萄糖750mg,2次/d,外加双氯酚酸钠缓释片75mg,1次/d,周期8周。使用Oswestry残疾指数、目测类比疼痛评分和SF-36量表在治疗前,治疗完成时和完成治疗后8周进行评估。结果与结论:33例完成最终的随访,男女比例为1:2,平均(41.2±10.3)岁。经过治疗,患者的腰痛和腿痛症状,腰椎功能和生活质量均有显著改善和提高(P<0.05)。提示,盐酸氨基葡萄糖与小剂量非类固醇类抗炎药物联用对小关节退变伴腰痛患者有一定治疗作用。

关 键 词:盐酸氨基葡萄糖  非类固醇类抗炎药  腰椎  小关节  退变  下腰痛  

Clinical outcome of glucosamine hydrochloride combined with non-steroid anti-inflammatory drug for degenerative facet joint and low back pain
Shi Rui,Liu Hao,Hu Tao,Ding Chen.Clinical outcome of glucosamine hydrochloride combined with non-steroid anti-inflammatory drug for degenerative facet joint and low back pain[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(26).
Authors:Shi Rui  Liu Hao  Hu Tao  Ding Chen
Institution:Shi Rui1,2,Liu Hao1,Hu Tao1,Ding Chen11Department of Orthopedics,2 Science and Technology Development Center,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China
Abstract:BACKGROUND:Glucosamine hydrochloride in the treatment of knee osteoarthritis has been confirmed for its safety and reliability due to the function of inflammation control,repairing cartilage and improving joint function.However,glucosamine hydrochloride drugs combined with non-steroid anti-inflammatory drug(NSAID) for low back pain are rarely reported.OBJECTIVE:To evaluate the clinical effectiveness of glucosamine hydrochloride combined with NSAID for facet joint degeneration and low back pain.METHODS:A tot...
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