| 早期生长反应基因1启动子介导肿瘤基因-放疗的研究进展 |
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| 引用本文： | 郭睿,李彪.早期生长反应基因1启动子介导肿瘤基因-放疗的研究进展[J].国际放射医学核医学杂志,2010,34(4). |
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| 作者姓名： | 郭睿 李彪 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院核医学科,200025 |
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| 基金项目： | 国家自然科学基金，上海市科委生物医药重点科技攻关项目，上海市教委重点学科建设基金 |
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| 摘 要： | 早期生长反应基因1(Egr-1)启动子为Egr-1上游的顺式作用元件,其活性受电离辐射、自由基等诱导剂的调控.Egr-1与治疗基因结合(如肿瘤坏死因子α基因、自杀基因等)构成基因-放射治疗体系,利用辐射在肿瘤局部从时间、空间调控治疗基因的表达,使表达产物局限于肿瘤局部发挥肿瘤杀伤效应,并降低了不良反应.放射治疗与基因治疗的结合为肿瘤治疗提供了新方法.
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| 关 键 词： | 基因表达调控 放射疗法 肿瘤 早期生长反应基因1 启动区(遗传学) |
The progress of tumor gene-radiotherapy induced by Egr-1 promoter |
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| GUO Rui,LI Biao.The progress of tumor gene-radiotherapy induced by Egr-1 promoter[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(4). |
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| Authors: | GUO Rui LI Biao |
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| Abstract: | The promoter of early growth response gene-1 (Egr-1) is a cis-acting element of Egr-1, and its activity is regulated by inducers such as ionizing radiation, free radical. In designated gene-radiotherapy system, radiation combined with therapeutic gene (such as tumor necrosis factor-α gene, suicide gene) can spatially and temporally regulate therapeutic gene expression in the irradiated field, produced a marked effect,while little systemic toxicities were observed. The combination of radiotherapy and gene therapy is promising in tumor therapy. |
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| Keywords: | Gene expression regulation Radiotherapy Naoplasms Early growth response gene-1 Promoter regions(genetics) |
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