Interaction of Hemoglobin Lepore with Sickle Cell Trait and Microcythemia (Thalassemia) in a Southern Italian Family |
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| Authors: | SILVESTRONI, EZIO BIANCO, IDA BAGLIONI, CORRADO |
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| Affiliation: | 1 Centro di Studi della Microcitemia e delle Anemie Microcitemiche, Istitutod’Igiene, Citta’ Universitaria, Rome, Italy and the International Laboratory of Geneticsand Biophysics, Naples, Italy.
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| Abstract: | An abnormal hemoglobin has been observed in a southern Italian familytogether with sickle cell hemoglobin and thalassemia (microcythemia). Thehematologic study has shown that all the carriers of the abnormal hemoglobinare microcythemic. The hemoglobins of these individuals have been studiedby paper, starch gel, starch block and agar gel electrophoresis. The abnormalhemoglobin has been isolated and identified by fingerprinting as HbLeporeBoston. The combination of Hb LeporeBoston with thalassemia and sicklecell trait has been observed in members of this family. The hematologic andbiochemical implications of the Hb Lepore/thalassemia disease are discussed. Submitted on March 23, 1964 Accepted on July 2, 1964 |
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