麻黄碱对维库溴铵预给药方法插管条件的影响

目的:探讨预注麻黄碱对维库溴铵预给药方法插管条件的影响。方法:60例患者随机分为对照组和麻黄碱组,每组30例,对照组维库溴铵预给药后注入等量生理盐水;麻黄碱组维库溴铵预给药后注入麻黄碱。麻醉诱导后采用Cooper's标准行插管条件评分,并记录插管前和插管后5 min患者平均动脉压和心率。结果:麻黄碱组诱导后下颌松弛度评分和插管反应评分均优于对照组(P0.05和P0.01),声门位置评分2组差异无统计学意义(P0.05),麻黄碱组30例患者、对照组23例患者诱导后呈现临床可接受的插管条件,差异有统计学意义(P0.05)。麻黄碱组诱导后较对照组有短时间平均动脉压增高和心率增快(P0.05～P0.01)。结论:预注麻黄碱显著改善维库溴铵预给药方法的插管条件。

Effects of ephedrine on intubating conditions following priming with vecuronium

Objective:To investigate if ephedrine could significantly improve intubating conditions following priming with vecuronium.Methods:Sixty patients were randomly divided into control group and ephedrine group,30 patients in each group.Control group was defined by normal saline following priming with vecuronium and ephedrine group was defined by ephedrine following priming with vecuronium.Intubating condition score was done according to Cooper′s criteria after anesthesia induction,and mean arterial pressure and heart rate before and after 5 minutes after intubation were recorded.Results:Jaw relaxation score and diaphragmatic response score in ephedrine group were markedly better than control group(P<0.05 and P<0.01),but no significant differences of vocal cord position score was found between these two groups(P>0.05).Intubating conditions were clinically acceptable in all patient in ephedrine group and 23 patients in control group after induction(P<0.05).Compared with control group,elevated mean arterial pressure and increased heart rate emerged after intubation in ephedrine group(P<0.05-P<0.01).Conclusions:Ephedrine can significantly improved intubating conditions following priming with vecuronium.