Survivin在脑膜瘤中的表达及其与p53、PCNA相关性研究

目的:探讨Survivin在脑膜瘤中的表达及与p53、PCNA相关性。方法:应用免疫组化SP法检测97例脑膜瘤组织、18例正常脑膜组织中survivin、p53、PCNA蛋白表达情况,结果进行统计学分析。结果:Survivin在脑膜瘤组织中表达的阳性率(65.9%)明显高于正常脑膜组织中的表达(0%)(P<0.001)。Survivin在脑膜瘤Ⅱ级(85.7%)和Ⅲ级(93.8%)中阳性表达率均明显高于脑膜瘤I级(51.7%)(P<0.001)。Survivin同p53表达共阳性23例,共阴性29例,两者的表达呈正相关(rs=0.451,P<0.01)。Survivin与PCNA蛋白表达共阳性45例,共阴性24例,两者的表达呈正相关(rs=0.640,P<0.01)。结论:Survivin是脑膜瘤形成和发展过程中重要的抗凋亡基因之一。Survivin与p53、PCNA在脑膜瘤的发生、增殖和恶化过程中可能起协同作用,其详细机制有待进一步研究。

Expression of survivin and its correlation with p53, PCNA in Meningiomas.

Objective: To explore the expression of survivin and its correlation with p53, PCNA in meningiomas. Methods: The expression of survivin, p53 and PCNA was detected in 97 meningiomas and 18 normal brain meninges by S-P immunohistochemical method; the results were statistically analyzed. Results: The expression of survivin in meningiomas (65.9%) was significantly higher than that in normal brain meninges (0%) (P<0.001). The rate of positive survivin expression in grade Ⅱ meningioma (85.7%) or grade Ⅲ (93.8%) was much significantly higher than that in grade Ⅰ (51.7%)(P<0.001). Of 97 cases, both of survivin and p53 expression were found in 23 patients, and negative expression in 29 cases (rs=0.451,P<0.01). And there were 45 patients who had both survivin and PCNA expression, 24 patients had negative expression of them (rs=0.640,P<0.01). Conclusion: Survivin is one of important antiapoptosis genes in meningioma occurrence and progress. Survivin may play a synergetic role with p53、PCNA in the oncogenesis, proliferation and malignancy of meningioma. The detailed mechanisms need be further studied.