The use of parathyroid hormone in the treatment of osteoporosis |
| |
Authors: | Monica Girotra Mishaela R Rubin John P Bilezikian |
| |
Institution: | (1) Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W. 168th Street, New York, NY 10032, USA;(2) Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W. 168th Street, New York, NY 10032, USA |
| |
Abstract: | Anabolic skeletal agents have recently broadened our therapeutic options for osteoporosis. By directly stimulating bone formation,
they reduce fracture incidence by improving bone qualities in addition to increasing bone mass. Teriparatide recombinant
human parathyroid hormone(1–34)], the only anabolic agent currently approved in the United States for osteoporosis, has emerged
as a major therapeutic approach to selected patients with osteoporosis. Teriparatide is approved for both postmenopausal women
and men with osteoporosis who are at high risk for fracture. With the use of this anabolic agent, bone density and bone turnover
increase, microarchitecture improves, and bone size is beneficially altered. The incidence of vertebral and nonvertebral fractures
is reduced with teriparatide use. Combination therapy with parathyroid hormone and an antiresorptive does not appear to offer
definitive advantages over the use of PTH or an antiresorptive alone, although recent ideas about combining these agents may
offer new insights. In order to maintain increases in bone density acquired during PTH therapy, it is important to follow
its use with an antiresorptive agent. |
| |
Keywords: | Parathyroid hormone (as treatment for osteoporosis) Osteoporosis (treatment) Teriparatide Anabolic skeletal agents (parathyroid hormone) |
本文献已被 PubMed SpringerLink 等数据库收录! |
|