经桡动脉血栓抽吸在急诊经皮冠状动脉介入治疗中的应用

目的：评价经桡动脉血栓抽吸在血栓负荷过重急性冠状动脉综合征急诊经皮冠状动脉介入治疗（PCI）中的应用效果、安全性和可行性。方法选择符合急诊PCI治疗条件的急性冠状动脉综合征患者56例，将PCI中应用ThrombusterⅡ血栓抽吸导管的31例作为试验组，未应用血栓抽吸导管的25例患者作为对照组。比较两组患者住院期间主要不良心脏事件（MACE）的发生率、术后1周左心室射血分数（LVEF）和左心室舒张末期内径（LVEDD）、手术前后的心肌梗死TIMI血流情况。结果试验组患者住院期间总MACE发生率（3.3%）低于对照组（12.0%），两组间差异有统计学意义（P＜0.05）；试验组术后TIMI Ⅲ级与出院前LVEF值高于对照组，两组间的差异有统计学意义（P＜0.05）；但两组间LVEDD的差异无统计学意义（P＞0.05）。结论初步结果提示，血栓抽吸结合经桡动脉直接PCI操作简单，有较好的安全性、可行性。

The application of trans-radial thrombus aspiration device in primary coronary interventional therapy

Objective To evaluate the effectiveness, safety and feasibility of the application of trans-radial thrombus aspiration in patient with heavy burden of thrombus receiving primary coronary interventional therapy. Methods 56 patients with acute coronary syndrome receiving primary coronary interventional therapy were enrolled and randomized to two groups. 31 patients received therapy of thrombus aspiration by Thrombuster II, while 25 patients received routine coronary interventional therapy. We compared the rate of major adverse cardiac event （MACE） in hospital, left ventricular ejection fraction （LVEF） one week post procedure and left ventricular end diastolic diameter （LVEDD）, TIMI frame before and after procedure between two groups. Results The rate of MACE was signiifcantly （P〈0.05） lower in patients receiving thrombus aspiration （3.3%） compared with routine PCI group （12.0%）. LVEF and the rate of patients with TIMI Ⅲafter procedure were signiifcantly （P 〈 0.05） higher in patients receiving thrombus aspiration. There’s no significant difference in LVEDD between two groups. Conclusions There lies good safety and feasibility for applying thrombus aspiration combining direct PCI in patient with heavy burden of thrombus.