| THE DIFFERENCES OF SERUM CHOLESTEROL AND LIPOPROTEINS IN ANIMALS SUSCEPTIBLE AND NONSUSCEPTIBLE TO ATHEROSCLEROSIS |
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| 引用本文： | 王克勤,何锦麟,唐京京,王健美,李志高,李宪周,吴钢,薛红,郝杄林,章惠珍,陈保生,胡咏悔. THE DIFFERENCES OF SERUM CHOLESTEROL AND LIPOPROTEINS IN ANIMALS SUSCEPTIBLE AND NONSUSCEPTIBLE TO ATHEROSCLEROSIS[J]. 中国医学科学杂志(英文版), 1990, 0(2) |
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| 作者姓名： | 王克勤 何锦麟 唐京京 王健美 李志高 李宪周 吴钢 薛红 郝杄林 章惠珍 陈保生 胡咏悔 |
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| 作者单位： | Institute of Basic Medical Sciences CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing，Institute of Basic Medical Sciences，CAMS，Beijing |
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| 基金项目： | This investigation was supported by grants from the National Committee of Science and Technology and from the Chinese Ministry of Public Health，and was reported in the International Symposium on Cardiovascular Medicine and Surgery.1987,Beijing. |
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| 摘 要： | The differences of serum lipid and lipoprotein (LP,profiles of animals susceptible (rabbit)and nonsusceptible (Beijing duck) to atherosclerosis as well as the distribution of apolipo-protein (apo) A-I and its catabolism in vivo were studied.Eight items,i.e.total cholesterol(TC),high density lipoprotein (HDL) cholesterol,triglyceride,percentage of a-LP and β-LP,β-LP concentration,lecithin cholesterol acyl transferase (LCAT),and agarose and polyacryla-mide gel electrophoresis of both species were assayed before and after feeding a high fat,high cholesterol diet.Results indicate that the exogenous cholesterol consumed by Beijingducks was carried and transported by HDL,while that in rabbits was transported by lowdensity lipoprotein (LDL).The biological half lives of apo A-I in serum and in HDL were41.11±2.4 and 42.8±1.7 h respectively.and its distribution in different organs was in theorder of liver>kidney>spleen>lung>heart>intestine>muscles>aorta.These resultsshow that the liver is the major organ for metabolizing HDL apo A-I.and the kidneyis also important.The results also imply that in Beijing ducks the cholesterol carried byHDL may be catabolized through apo A-I receptors in the liver and kidney.The differencesin cholesterol binding and in lipoprotein and apolipoprotein metabolism of the two speciesprovide important clues for the elucidation of the pathogenesis of atherosclerosis.
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| 关 键 词： | atherosclerosis metabolism cholesterol (Ch) HDL-Ch α-LP β-LP Apo A-I LCAT |
THE DIFFERENCES OF SERUM CHOLESTEROL AND LIPOPROTEINS IN ANIMALS SUSCEPTIBLE AND NONSUSCEPTIBLE TO ATHEROSCLEROSIS |
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| Wang Keqin He Jinlin Tang Jingjing Wang Jianmei Li Zhigao Li Xianzhou Wu Gang Xue Hong HaoQianlin Zhang Huizhen Chen Baosheng Hu Yongmei institute of Basic Medical Sciences,CAMS,Beijing. THE DIFFERENCES OF SERUM CHOLESTEROL AND LIPOPROTEINS IN ANIMALS SUSCEPTIBLE AND NONSUSCEPTIBLE TO ATHEROSCLEROSIS[J]. Chinese medical sciences journal, 1990, 0(2) |
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| Authors: | Wang Keqin He Jinlin Tang Jingjing Wang Jianmei Li Zhigao Li Xianzhou Wu Gang Xue Hong HaoQianlin Zhang Huizhen Chen Baosheng Hu Yongmei institute of Basic Medical Sciences CAMS Beijing |
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