超声引导无水乙醇注射治疗甲状腺良性包块的临床观察

目的:观察甲状腺良性包块应用经皮无水乙醇注射(PEI)技术进行治疗的临床疗效。方法:62例甲状腺良性包块患者,其中实性包块者36例、囊性包块26例,在超声引导下行局部无水乙醇注射治疗。结果:对于实性包块患者,PEI治疗后12月,包块体积由治疗前的(4.6±0.8)ml缩小到(1.4±0.4)ml(P<0.01),平均缩小70%,有效率和治愈率分别为64%与33%,临床疗效随时间的延长有明显提高的趋势。囊性包块患者治疗后包块容积由(6.5±1.9)ml减少为(0.7±0.3)ml(P<0.001),平均缩小近90%,有效率和治愈率分别为96%和80%;其中90%的实性包块进行了2次及以上治疗,而囊性包块患者中进行1次治疗的占81%。主要副作用为局部疼痛和轻度水肿。结论:超声引导无水乙醇注射治疗甲状腺良性包块的临床疗效显著,囊性包块更优于实性包块,且副作用少,不影响美观,对甲状腺功能无影响。

Ultrasound-guided Percutaneous Ethanol Injection in Treatment of Benign Thyroid Nodules

Objective: To investigate the efficacy of percutaneous ethanol injection(PEI) guided by ultrasonography on the treatment of benign thyroid nodules.Methods: Sixty-two cases of benign thyroid nodules including 36 solid types and 26 cystic types were injected with anhydrous ethanol locally guided by ultrasonography.Results: One year after the treatment,volume of solid nodules decreased from(4.6±0.8)ml to(1.4±0.4)ml(P<0.01),the mean percentage of shrinkage was 70%,the rate of efficacy and cure was 64% and 33% respectively.At the same follow-up period,volume of cystic nodules dropped from(6.5±1.9)ml to(0.7±0.3)ml(P<0.001),the mean rate of shrinkage was 90%,the rate of efficacy and cure was 96% and 88% respectively.Conclusion: PEI method is effective and safe in treating benign thyroid nodules,and the efficacy on cystic nodules is significant higher than that on solid nodules.