Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis |
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| Authors: | Leo Jeng Alexandra V Yamshchikov Suzanne E Judd Henry M Blumberg Gregory S Martin Thomas R Ziegler Vin Tangpricha |
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| Affiliation: | (1) Division of Endocrinology, Diabetes & Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA;(2) Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA;(3) Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, USA;(4) Division of Pulmonary and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA;(5) Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA;(6) Atlanta VA Medical Center, Decatur, Georgia |
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| Abstract: | Background Vitamin D insufficiency is common in hospitalized patients. Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial peptide produced by macrophages and neutrophils. Thus, the relationship between vitamin D status and LL-37 production may be of importance for host immunity, but little data is available on this subject, especially in the setting of human sepsis syndrome and other critical illness. |
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