| 奥氮平与氯丙嗪治疗精神分裂症的对照研究 |
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| 引用本文： | 安松梅,李言波,于东玲.奥氮平与氯丙嗪治疗精神分裂症的对照研究[J].中国民康医学,2011,23(10):1196-1197,1277. |
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| 作者姓名： | 安松梅 李言波 于东玲 |
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| 作者单位： | 烟台市心理康复医院,山东莱阳,265200 |
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| 摘 要： | 目的:探讨奥氮平治疗精神分裂症的疗效及不良反应。方法:将213例精神分裂症患者随机分为研究组(奥氮平)和对照组(氯丙嗪),共治疗8周。治疗前后应用简明精神病评定量表(BPRS)、住院患者观察量表(NOSIE)和副反应量表(TESS)分别评定疗效及不良反应。结果:在治疗第2周末、第8周末,研究组的BPRS各因子分及总分均低于对照组,差异具有显著性意义(P<0.05),研究组的NOSIE的社会功能、个人整洁、总积极因素因子分及病情总估计分均高于对照组,抑郁、迟缓及总消极因素因子分均低于对照组,差异也具有显著意义(P<0.05)。奥氮平的不良反应明显少于氯丙嗪。结论:奥氮平可有效改善精神分裂症患者的精神病症状和社会功能。
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| 关 键 词： | 奥氮平 氯丙嗪 精神分裂症 |
Comparetive study of Olanzapine and Chlorpromazine in the treatment of schizophrenia |
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| AN Song-mei,LI Yan-bo,YU Dong-ling.Comparetive study of Olanzapine and Chlorpromazine in the treatment of schizophrenia[J].medical journal of chinese peoples health,2011,23(10):1196-1197,1277. |
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| Authors: | AN Song-mei LI Yan-bo YU Dong-ling |
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| Institution: | AN Song-mei,LI Yan-bo,YU Dong-ling(Psychological Rehabilitation Hospital of Yantai,Laiyang 265200,China) |
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| Abstract: | Objective:To study efficacy and adverse effects of Olanzapine in treatment of schizophrenia.Methods:A total of 213 patients with schizophrenia were randomly divided into study group with Olanzapine and control group with Chlorpromazine for treatment of 8 weeks.They were assessed and analysed conlrastively using Brief Psychiatric Rating Scale(BPRS),Nurses Observation Scale(NOSIE) and Treatment Emergent Side Effect Scale(TESS).Results:In the second weedend and eighth weekend of treatment,the total and factors... |
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| Keywords: | Olanzapine Chlorpromazine Schizophrenia |
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