三虫半夏白术天麻汤对痰瘀互阻型头痛患者症状及血清同型半胱氨酸的影响

目的探讨痰瘀互阻型头痛与血清同型半胱氨酸（HCY）之间的相关性并观察三虫半夏白术天麻汤对痰瘀互阻型头痛的疗效及对血清HCY的影响。方法检测176例痰瘀互阻型头痛患者的血清HCY水平,并进行头痛积分及头痛中医证候评分。将HCY〉15μmol/L的患者80例随机分为2组。观察组予三虫半夏白术天麻汤,对照组予盐酸氟桂利嗪胶囊、叶酸片、维生素B6口服治疗。观察治疗2周、4周患者HCY水平、头痛积分及中医证候积分的变化情况。结果 176例痰瘀互阻型头痛患者中115例（65.34%）HCY值高于正常值,痰瘀互阻型头痛与HCY水平具有显著相关性。观察组患者头痛积分及中医证候综合积分疗效明显优于对照组。两组治疗4周后HCY值较治疗前明显降低;治疗2周后观察组HCY降低幅度明显低于对照组;治疗4周后,两组HCY降低幅度无显著差异。结论痰瘀互阻型头痛与血清HCY值具有显著相关性;三虫半夏白术天麻汤可改善痰瘀互阻型头痛患者头痛症状及中医证候,疗效显著,且无不良反应。

Effect of Sanchongbanxiabaizhutianma Decoction in Symptoms and Serum Homocysteine of Headache Patients with Phlegm and Blood Stasis Syndrome

Objective： To observe the therapeutic effects of Sanchongbanxiabaizhutianma Decoction in treating headache patients with phlegm and blood stasis syndrome and to research the association between homocysteine and this type headache.Methods： After HCY level detection and relative score in 176 patients,80 cases of headache with phlegm and blood stasis syndrome whose HCY value was greater than the patients of 15μmol / L were divided randomly into the observation group with Sanchongbanxiabaizhutianma Decoction and the control group with Sibelium,Folic Acid,vitB6 and vitB12.After 2 weeks and 4 weeks,the HCY level,the headache score and the TCM syndrome score were observed in 2 groups.Results： In 176 cases of headache with phlegm and blood stasis syndrome,HCY levels of 115 patients were more than the normal value.There was a significant correlation between the phlegm and blood stasis syndrome and the HCY concentration.The headache score and the TCM syndrome score in the observation group were significantly superior to those in the control group.After 4 weeks,HCY levels in 2 groups were decreased remarkably.After 2 weeks,the degree of HCY reduction in the observation group was less obviously than that in the control group.However,there was no statistical difference of HCY reduction between 2 groups after 4 weeks.Conclusion： There is a significant correlation between the headache with phlegm and blood stasis syndrome and the serum HCY level.Sanchongbanxiabaizhutianma Decoction can improve the symptoms and the TCM syndrome of headache patients with phlegm and blood stasis syndrome.It has the definite therapeutic effect and no adverse reaction.