| 文拉法辛治疗脑卒中后抑郁疗效观察 |
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| 引用本文： | 童自谨,李艳春.文拉法辛治疗脑卒中后抑郁疗效观察[J].医学临床研究,2009,26(7):1234-1235. |
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| 作者姓名： | 童自谨 李艳春 |
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| 作者单位： | 1. 怀化市第四人民医院精神科,湖南,怀化,418000
2. 怀化市第三人民医院神经内科,湖南,怀化,418000 |
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| 摘 要： | 【目的】观察文拉法辛治疗脑卒中后抑郁（PSD）患者的疗效和不良反应。【方法】72例PSD患者分为文拉法辛组和阿米替林组各36例，于治疗前及治疗后第2周，第4周，第6周对两组患者进行hamilion抑郁量表（HAMD）和副反应量表（TESS）评定。【结果】治疗后，两组患者的HAMD评分均较治疗前明显降低（P〈0．01），但两组间无显著差异（P〉0．05），文拉法辛组的不良反应明显较阿米替林组少且轻（P〈0．01）。【结论】文拉法辛治疗PSD安全，有效。
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| 关 键 词： | 脑血管意外/并发症 抑郁症/药物疗法 抗抑郁药/治疗应用 |
Effect of Venlafaxine on Post-stroke Depression |
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| TONG Zi-jin,LI Yang-chun.Effect of Venlafaxine on Post-stroke Depression[J].Journal of Clinical Research,2009,26(7):1234-1235. |
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| Authors: | TONG Zi-jin LI Yang-chun |
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| Institution: | TONG Zi-jin , LI Yang-chun ( Department of Psychiatry, the Fourth People＇s Hospital of Huaihua City, Hunan 418000, China ) |
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| Abstract: | Objective] To observe the efficacy and side effects of venlafaxine in the treatment of post-stroke depression (PSD). Methods] Seventy two patients with PSD were randomly divided into venlafaxine group(n=36) and amitriptyline group(n=36). Before the treatment and at the end of 2nd, 4th and 6th week after the treatment, all patients in two groups were assessed with Hamilton Depression Scale (HAMD) and TESS. Results] After treatment, HAMD scores of patients of two groups were decreased significantly(P<0.01), but no difference was found between two groups (P>0.05). The side effects of the venlafaxine group were obviously fewer and milder than those of amitriptyline group (P<0.01). Conclusion] Venlafaxine is an effective and safe drug in the treatment of PSD. |
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| Keywords: | cerebrovascular disorders/CO depression/DT antidepressive agents/TU |
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