| 车前子对高脂血症大鼠脂质过氧化的影响 |
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| 引用本文： | 王素敏,张杰,李兴琴,朱树森.车前子对高脂血症大鼠脂质过氧化的影响[J].营养学报,2003,25(2):212-214. |
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| 作者姓名： | 王素敏 张杰 李兴琴 朱树森 |
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| 作者单位： | 1. 河北医科大学药理教研室
2. 河北省医学科学院生化研究室,石家庄,050021 |
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| 基金项目： | 河北省科技厅基金(N o.992 76 2 14 D) |
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| 摘 要： | 目的 : 探讨车前子对高脂血症大鼠脂质过氧化的影响。方法 : 采用大鼠血清及多脏器组织 ,观察车前子对高脂血症大鼠脂质过氧化的影响。结果 : 高脂对照组血清和心肌超氧化物歧化酶 ( SOD)活性显著降低 ,而脂质过氧化物 ( LPO)含量明显升高 ,血清和肝脏的过氧化氢酶( CAT)、谷胱苷肽过氧化物酶 ( GSH-Px)活性明显降低。补充车前子后显著升高血清及心肌组织SOD活性 2 2 %和 2 8% ,以及肝脏 GSH-Px活性 2 2 %。而使血清及心肌的 LPO含量分别下降 3 2 %和 1 7%。结论 : 1 5 g/kg车前子可提高高脂血症大鼠体内抗氧化能力并免受自由基损伤
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| 关 键 词： | 车前子 高脂血症 脂质过氧化 |
| 文章编号： | 0512-7955(2003)02-0212-03 |
| 修稿时间： | 2002年3月18日 |
EFFECT OF PLANTAGO ASIATICA L. SEED ON THE ANTIOXIDATION IN RATS |
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| WANG Su min,ZHANG Jie,LI Xing qin,ZHU Shu sen.EFFECT OF PLANTAGO ASIATICA L. SEED ON THE ANTIOXIDATION IN RATS[J].Acta Nutrimenta Sinica,2003,25(2):212-214. |
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| Authors: | WANG Su min ZHANG Jie LI Xing qin ZHU Shu sen |
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| Abstract: | Objective: To investigate the effect of Plantago asiatica L. on antioxidation in rats. Methods: The antioxidative enzymes and LPO of serum, heart, and liver tissues were determined. Results: The activities of superoxide (SOD) in serum and heart were significantly lower than that of the control. The lipid peroxide (LPO) level in serum and heart was markedly higher than that of the control. Serum and liver catalase (CAT) activities in rats fed with high fat were decreased. Activities of liver glutathione peroxidase (GSH Px) in high fat rats were decreased significantly. The production of SOD activities in serum and liver and GSH Px in liver were increased significantly in rats maintained on Plantago asiatica L. supplemented diets, meanwhile serum and heart LPO were reduced. Conclusion: 15g/kg Plantago asiatica L. can increase the antioxidation against lipid peroxide in hyperlipidemic rats. |
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| Keywords: | Plantago asiatica L seed hyperlipidemia lipid peroxide |
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