一服清颗粒治疗上呼吸道感染的药效学研究

目的：探讨一服清颗粒治疗上呼吸道感染的药效学机制。方法：观察一服清颗粒对三联菌苗所致兔发热的影响;采用小鼠热板法观察一服清颗粒对小鼠痛阈的影响;观察一服清颗粒对二甲苯所致小鼠耳廓炎性肿胀的影响;采用小鼠体内抑菌实验观察一服清颗粒对金葡菌感染小鼠死亡率的影响;采用细胞病变法观察一服清颗粒对病毒致细胞病变作用的影响。结果：一服清颗粒对三联菌苗所致兔发热有显著的退热作用；可明显提高热板引起的小鼠痛阈值；能抑制二甲苯所致小鼠耳廓炎性肿胀；有效降低金葡菌感染小鼠死亡率，对金黄色葡萄球菌造成的小鼠体内感染有较好的保护作用；对呼吸道合胞病毒(RSV)、腺病毒(Ad3)具有明显的抑制作用。结论：一服清颗粒是治疗上呼吸道感染的有效药物，具有显著的解热、镇痛、消炎、抑菌及抗病毒的作用。

Pharmacodynamic study of the Yifuqing granula on upper respiratory infection

Objective: To investigate the pharmaco-mechanism of the Yifuqing granula on upper respiratory infection.Methods: The Yifuqing granula was given to rabbit with febrilis caused by the TAB vaccine.The effects of the Yifuqing granula on the ache threshold value of Jimpy mice caused by Hot plate,on auricle inflammatory swelling of Jimpy mice caused by dimethyl benzene,on the bacterium of Jimpy mice in vivo,and on CPE caused by virus were observed.Result: The Yifuqing granula prominently relieved febrilis caused by the TAB vaccine,elevated the pain threshold of Jimpy mice caused by a hot plate,inhibited the swelling of Jimpy mice caused by dimethyl benzene,degraded the fatality of Jimpy mice infected by Staphylococcus aureus and effectively inhibited RSV and Ad3.Conclusion: The Yifuqing granula has an evident effect on relieving fever and pain,dephlogistication,bacteriostasis and anti-virus and it is effective in treating upper respiratory infection.