| 淋巴细胞转化时间对抗癌药敏感性的影响 |
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| 引用本文： | 周步全 陈科 孙海彦 陈国宁 李开吾. 淋巴细胞转化时间对抗癌药敏感性的影响[J]. 中华综合临床医学杂志(山东), 2005, 7(11): 903-905 |
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| 作者姓名： | 周步全 陈科 孙海彦 陈国宁 李开吾 |
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| 作者单位： | [1]江苏省盐城市第二人民医院,江苏盐城224003 [2]江苏省盐城市第一人民医院,江苏盐城 |
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| 摘 要： | 目的探讨淋巴细胞转化增殖能力的改变对抗癌药敏感性的影响。方法在正常人外周血淋巴细胞中加入植物血凝素（PHA）非特异性刺激淋巴细胞，分别培养0d、1d、2d、3d、4d、5d，加入抗癌药，用MTT法检测抗癌药对淋巴细胞的抑制率。结果淋巴细胞对抗癌药的敏感性随淋巴细胞转化增殖能力的增强而增高。结论抗癌药对细胞的抑制率与细胞转化增殖能力密切相关。
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| 关 键 词： | 淋巴细胞转化时间 抗癌药 药敏 MTT法 |
| 文章编号： | 1728-7324-（2005）011-0903-03 |
Effects of lymphocyte transformation time on sensitiveness of anticancer drugs |
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| Zhou Buquan , Chen Ke , Sun Haiyan , Chen Guoning , Li Kaiwu. Effects of lymphocyte transformation time on sensitiveness of anticancer drugs[J]. , 2005, 7(11): 903-905 |
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| Authors: | Zhou Buquan Chen Ke Sun Haiyan Chen Guoning Li Kaiwu |
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| Affiliation: | 1. YanCheng second hospital, Jiang su YanCheng 224003; 2. YanCheng first hospital |
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| Abstract: | Objective To explore the effect of the transformation and the proliferation lymphocyte on sensitiveness of anticancer drugs. Methods Add non-special stimulating factor PHA into the periphoral blood lymphocyte and cultured for 0d , 1d, 2d, 3d, 4d, 5d, then add respectively the anticancer drugs. Inhibit rate of anticancer on the lymphocyte was measured by MTT colorimetry. Result Sensitiveness of the lymphocyte on the anticancer increases as the ability of transformation and proliferation of the lymphocyte increased. Conclusion Inhibit rate of anticancer drugs on a cell closely related to a ability of transformation and proliferation of the cell. |
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| Keywords: | lymphocyte transformation time anticancer drugs sensitve drugs MTT colorimetry |
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