| 美洛昔康贴剂裸鼠经皮吸收的初步研究 |
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| 引用本文： | 郜琪臻,杨丽英,丁平田,何仲贵.美洛昔康贴剂裸鼠经皮吸收的初步研究[J].药学学报,2007,42(12):1320-1322. |
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| 作者姓名： | 郜琪臻 杨丽英 丁平田 何仲贵 |
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| 作者单位： | 1. 中国医科大学,第一附属医院,药剂科,辽宁,沈阳,110001
2. 沈阳药科大学,药学院,辽宁,沈阳,110016 |
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| 摘 要： | 美洛昔康是第1个上市的环氧合酶-2（COX-2）抑制剂，大量临床试验表明美洛昔康具较强的镇痛消炎作用，对骨关节炎、类风湿性关节炎、坐骨神经痛有较好的治疗效果。目前美洛昔康上市的主要剂型为片剂、胶囊剂、软膏剂及注射剂等。为了提高患者用药的安全性和依从性，增加美洛昔康的适用人群，开发了局部经皮给药制剂——美洛昔康贴剂。
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| 关 键 词： | 美洛昔康 微渗析 经皮吸收 贴剂 |
| 文章编号： | 0513-4870（2007）12-1320-03 |
| 收稿时间： | 2007-05-08 |
| 修稿时间： | 2007年5月8日 |
Percutaneous absorption of meloxicam patches in hairless mouse |
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| GAO Qi-zhen,YANG Li-ying,DING Ping-tian,HE Zhong-gui.Percutaneous absorption of meloxicam patches in hairless mouse[J].Acta Pharmaceutica Sinica,2007,42(12):1320-1322. |
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| Authors: | GAO Qi-zhen YANG Li-ying DING Ping-tian HE Zhong-gui |
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| Institution: | Department of Pharmacy, No. 1 Affiliated Hospital, China Medical University, Shenyang 110001, China. |
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| Abstract: | Meloxicam concentration in skin was determined following topical administration of meloxicam patches in hairless mouse. Samples were analysized by HPLC coupled with microdialysis sampling technique, in which in vivo recovery of probe was characterized by the retrodialysis method. It was indicated that the in vivo recovery of the probe was 14.0%. The range of steady state concentration of meloxicam in dialysate was 24-50 ng x mL(-1), and that was 170-360 ng x mL(-1) in the hairless mouse skin. Steady state concentration of meloxicam was reached shortly after the application of meloxicam patches, which was maintained during the period of experiment. |
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| Keywords: | meloxicam microdialysis percutaneous absorption patch meloxicam microdialysis percutaneous absorption patch |
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