Relationship between body fat mass,carbohydrate tolerance and iri response during glucose infusion in subjects with early diabetes |
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Authors: | Klaus-Peter Ratzmann Siegfried Knospe Peter Heinke Bernd Schulz |
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Institution: | (1) Zentralinstitut für Diabetes ‘Gerhardt Katsch’ Clinical Research Unit and Department of Experimental Diabetes Research, Karlsburg |
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Abstract: | Summary We have studied the interrelationship of total body fat mass, carbohydrate tolerance and IRI response in 17 non-obese and
obese subjects, who were suspected of having early diabetes. We carried out an i.v. glucose infusion test consisting of a
priming injection of 0.33 g/kg followed by constant glucose infusion of 12 mg/kg/min in all persons. Total body fat mass was
estimated by the tritium dilution method. There was a positive correlation of body fat mass, fasting glucose concentration
and blood glucose concentration at 150 min as well as a strong correlation between body fat mass and BG area 60–120 min as
parameters of carbohydrate tolerance in all subjects, i.e. the degree of carbohydrate intolerance was directly related to
the quantity of total body fat mass. A similar correlation was found when the non-obese and obese groups were analyzed separately.
In neither group did total body fat mass correlate with parameters of IRI response. In obese subjects with pathological carbohydrate
tolerance, however, a positive correlation of basal IRI concentration and total body fat mass was found. Furthermore, a close
relation between basal IRI level and parameters of carbohydrate tolerance could be demonstrated in obese subjects. The present
study failed to demonstrate any correlation of parameters of carbohydrate tolerance and glucose-induced IRI response in either
group. Thus, the significant relationship between body fat mass and degree of carbohydrate intolerance indicates that total
body fat mass plays an important role in the disturbance of blood glucose homeostasis in early diabetes with and without obesity.
Investigation performed within the medical research project ‘Diabetes mellitus and disturbances of lipid metabolism’, Ministry
of Health, GDR. |
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Keywords: | Body fat mass Carbohydrate tolerance Early diabetes Insulin response |
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