| TLR-2、MMP-9与胆脂瘤型中耳炎的关系 |
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| 引用本文： | 吴淑献,沈志忠. TLR-2、MMP-9与胆脂瘤型中耳炎的关系[J]. 医学综述, 2010, 16(7) |
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| 作者姓名： | 吴淑献 沈志忠 |
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| 作者单位： | 汕头大学医学院第一附属医院耳鼻咽喉头颈外科,广东,汕头,515041 |
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| 摘 要： | Toll样受体2(TLR-2)是一种跨膜受体,在病原体感染机体中可发挥天然免疫作用,并通过其胞内信号转导而连接获得性免疫。基质金属蛋白酶9(MMP-9)是一种可降解细胞外基质的内肽酶,其作用底物为Ⅰ、Ⅲ、Ⅳ、Ⅴ型胶原以及明胶等。近年来研究发现,相对于正常外耳道上皮、中耳的胆脂瘤上皮中TLR-2和MMP-9均为高表达。
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| 关 键 词： | Toll样受体2 基质金属蛋白酶9 胆脂瘤型中耳炎 发病机制 |
Relationship between TLR-2,MMP-9 and Otitis Media Cholesteatomatica |
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| WU Shu-xian,SHEN Zhi-zhong.. Relationship between TLR-2,MMP-9 and Otitis Media Cholesteatomatica[J]. Medical Recapitulate, 2010, 16(7) |
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| Authors: | WU Shu-xian SHEN Zhi-zhong. |
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| Affiliation: | WU Shu-xian,SHEN Zhi-zhong.(Department of Otorhinolaryngology-Head , Neck Surgery,First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China) |
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| Abstract: | Toll-like receptor 2(TLR-2)is a member of transmembrane receptors,which can induce the innate immunity when the body is infected by pathogens.It also enhances the acquired immunity through its intracellular signal transduction.Matrix metalloproteinase-9(MMP-9)is an endopeptidase,which can degrade extracellular matrix.Its substrates are collagens Ⅰ,Ⅲ,Ⅳ and Ⅴ,and gelatin.Recent studies showed that TLR-2 and MMP-9 were overexpressed in the epithelia of the middle ear cholesteatoma,in contrast to those in normal auditory canal epithelia. |
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| Keywords: | Toll like receptor-2 Matrix metalloproteinases-9 Otitis media cholesteatomatica Pathogenesis |
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