| 氨丁胍对RINm5F胰岛素分泌细胞ATP-调节的钾离子通道的抑制作用 |
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| 引用本文： | LIANG RiXin.氨丁胍对RINm5F胰岛素分泌细胞ATP-调节的钾离子通道的抑制作用[J].中国药理学与毒理学杂志,1998,12(2):149-150. |
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| 作者姓名： | LIANG RiXin |
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| 作者单位： | Institute of Chinese Materia Medica，China Academy of Traditional Chinese Medicine，Beijing 100700 |
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| 摘 要： | ＩｎｈｉｂｉｔｉｏｎｏｆＡＴＰ┐ｒｅｇｕｌａｔｅｄｐｏｔａｓｉｕｍｃｈａｎｎｅｌｓｂｙａｇｍａｔｉｎｅｉｎＲＩＮｍ５ＦｉｎｓｕｌｉｎｓｅｃｒｅｔｉｎｇｃｅｌｓＬＩＡＮＧＲｉ－Ｘｉｎ（ＩｎｓｔｉｔｕｔｅｏｆＣｈｉｎｅｓｅＭａｔｅｒｉａＭｅｄｉｃａ，Ｃｈ...
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| 关 键 词： | patchclamp technique agmatine ion channels potassium |
| 收稿时间： | 1997-1-20 |
Inhibition of ATP-regulated potassium channels by agmatine in RINm5F insulin secreting cells |
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| LIANG Ri-Xin.Inhibition of ATP-regulated potassium channels by agmatine in RINm5F insulin secreting cells[J].Chinese Journal of Pharmacology and Toxicology,1998,12(2):149-150. |
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| Authors: | LIANG Ri-Xin |
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| Institution: | （Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700） |
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| Abstract: | Effect of agmatine on ATP-regulated potassium (K＋ATP)channels was studied using patch-clamp technique in RINm5F insulin- secreting cells. It was found that agmatine 0.1 and 1.0 mmol·L-1 applied to inside face of plasma membrane inhibited openings of K＋ATP channels, and reduced related open-state probability. The inhibition was reversal and concentration- dependent. The data indicate that agmatine may promote insulin secretion from β-cells through interaction with K＋ATP channels. |
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| Keywords: | patch-clamp technique agmatine ion channels potassium |
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