Synthesis and pharmacological studies of some pyrone and benzodifuran derivatives |
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| Authors: | Orchidee H Hishmat Hoda I El-Diwani Sherifa M A Bakr Sawsan S Mahmoud Somaya A Nada |
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| Institution: | 1. Chemistry of Natural and Microbial Products Deprtment, National Research Center, Dokki, Cairo, Egypt
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| Abstract: | The michael adducts2a,b were obtained from the reaction of the phenylacetyl derivative1 with benzaldehyde and p-anisaldehyde respectively.2a and2b were subjected to react with cyanoethanoic acid hydrazide, malononitrile, cyanothioacetamide, cyanoacetamide and 1,1,3-tricyano-2-amino
propene to yield4a-h and5a,b respectively. Hydrogen peroxide oxidation of2a,b gave the aurone derivative6a,b. The pyrone derivatives8a,b were obtained from2a,b by addition of chloroacetyl chloride followed by dehydrochlorination. |
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| Keywords: | Chalcones Michael aducts Antiinflammatory agents Anticoagulants |
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