| 再生障碍性贫血患者DNA损伤修复活性检测 |
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| 引用本文： | 魏旭东,黄明宜,张伟,张秋霞,李国玲,赵志平.再生障碍性贫血患者DNA损伤修复活性检测[J].郑州大学学报(医学版),1994(3). |
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| 作者姓名： | 魏旭东 黄明宜 张伟 张秋霞 李国玲 赵志平 |
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| 作者单位： | 河南医科大学第一附属医院内科，郑州市第五人民医院，郑州第六棉纺织厂医院 |
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| 摘 要： | 用盐酸氮芥和紫外线作为ＤＮＡ损伤修复诱导剂，对２４例再生障碍性贫血（再障）骨髓单个核细胞及３３例再障外周血单个核细胞的ＤＮＡ损伤修复活性进行了检测。发现再障患者的脱氧核糖核酸损伤修复活性明显低于正常（Ｐ＜０．０５），其低下与患者贫血程度、骨髓增生状况无关，临床治疗也不易纠正。提示患者ＤＮＡ修复活性低下可能在再障的发生中起重要作用。
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| 关 键 词： | 再生障碍性贫血 DNA 盐酸氮芥 紫外线 |
DNA repair in patients with aplastic anemia |
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| Wei Xudong,Huang Mingyi,Zhang Wei,Zhang Qiuxia,Li Guoling,Zhao Zhiping.DNA repair in patients with aplastic anemia[J].Journal of Zhengzhou University: Med Sci,1994(3). |
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| Authors: | Wei Xudong Huang Mingyi Zhang Wei Zhang Qiuxia Li Guoling Zhao Zhiping |
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| Abstract: | The extent of DNA repair induced by nitrogen mustard and UV-light irradiation was measured in the peripheral mononuclear cells of 33 patients with AA and the bone marrow mononuclear cells of 24 patients with AA.The results showed that the DNA repair synthesis activity of the patients was significantly lower than that of the control(P<0.05).The extents of the DNA repair were not correlated to the extents of anemia and bone marrow proliferation.The clinical treatment could not correct this defect.This suggested that the defects of DNA repair synthesis activity played an important role in the pathogenic mechanism of some patients with AA. |
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| Keywords: | aplastic anemia DNA nitrogen mustard UV-light |
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