脑损伤患者的康复结局与血清谷氨酸水平的相关性研究

探讨脑外伤患者的康复结局与血清谷氨酸（ＧＬＵ）水平的相关性。方法采用高效液相色谱法（ＨＰＬＣ）测定３０例急性脑外伤患者外伤患者伤后２４ｈ内和６ｄ的血清谷氨酸，在并在２４小时内采用格拉斯哥昏迷计分（ＧＣＳ）及２０ｄ后功能独立性（ＦＩＭ）的评定值进行相关性研究。

Correlation between plasmatic glutamic acid level and rehabilitation of patients with brain injury

Objective To study correlation between plasmatic glutamic (GLU) acid level with rehabilitation of patients with brain injury. Methods By high-performance liquid chromatography, we determined the plasmatic glutamic acid concentration of patients within 24 hours and 6 days after brain injury and made relative analysis with Glasgow coma scale (GCS) within 24 hours and function independence measure (FIM) after 20 days. Results The concentration of plasmatic glutamic acid within 24 hours was well negatively correlated to GCS and FIM. A comparison of the concentration of plasmatic glutamic acid in 24 hours and that in 6 days showed two different groups, i.e. GLU concentration continuous increase group and GLU concentration decrease group. There was a significant difference ( P <0.01) that FIM score in the GLU concentration increase group was far lower than that of the GLU concentration decrease group according to mean score of FIM after 20 days in two groups. Conclusions The concentration of glutamic acid in patients' plasma effects secondary cerebral damage and recovery of patients.