| Box-Behnken响应面法优选豨桐凝胶贴膏的提取工艺 |
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| 引用本文： | 黄诗莹,张丽娟,柯龙华,彭云娇,刘瑶,沈芸霞,陈远云,何琳,滕希峰.Box-Behnken响应面法优选豨桐凝胶贴膏的提取工艺[J].广东药学院学报,2017,33(1). |
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| 作者姓名： | 黄诗莹 张丽娟 柯龙华 彭云娇 刘瑶 沈芸霞 陈远云 何琳 滕希峰 |
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| 作者单位： | 1. 广东药科大学 中药学院/国家中医药管理局岭南药材生产与开发重点研究室,广东 广州,510006;2. 广东药科大学 医药化工学院/广东省化妆品工程技术研究中心,广东 中山,528458 |
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| 基金项目： | 广东药学院"创新强校工程"医药化工省级实验教学示范中心资助项目，广东药学院2015年大学生创新创业培育项目，广东药学院2015国家级大学生创新创业训练计划项目，广东药学院中药学院创新训练资助项目，"挑战杯"广东药学院创业计划竞赛2015年 |
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| 摘 要： | 目的 优化豨桐凝胶贴膏的回流提取工艺条件.方法 以豨莶草的有效成分奇壬醇、臭梧桐的有效成分芹菜素及干膏得率为考察指标,以Box-Behnken响应面法进行工艺优化,研究加水量、提取时间及提取次数对考察指标的影响.结果 豨桐凝胶贴膏最佳提取工艺为12倍水,每次2 h,提取3次.采用优选出的工艺进行提取,奇壬醇质量分数为2.568 mg/g,芹菜素质量分数为0.05589 mg/g,干膏率为22.09%.结论 该优选工艺稳定可行,为豨桐凝胶贴膏的制备奠定了基础.
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| 关 键 词： | 豨莶草 臭梧桐 凝胶贴膏 Box-Behnken响应面法 提取工艺 |
Study on extraction technology of Xitong gel plasters with Box-Behnken response surface method |
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| Abstract: | Objective To optimize the extraction process of the Xitong gel plasters. Methods The yields of kirenol ( Siegesbeckia orientalis ) , apigenin ( Clerodendrum trichotomum Thunb ) and dry extract were evaluated as indexes. Box-Behnken response surface method was conducted to optimize the extraction process with three factors of water addition amount, extraction time and extraction times. Results The optimal conditions of extraction process were as follows: adding 12 times of water, refluxing 3 times and 2 h for each time. The content of kirenol in Siegesbeckia orientalis was 2.568 mg/g, and the content of apigenin in Clerodendrum trichotomum Thunb was 0.05589 mg/g. The yield of dry extract was 22.09%. Conclusion The optimized extraction technology was practical and stable which could lay a foundation for the preparation for Xitong gel plasters. |
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| Keywords: | Siegesbeckia orientalis Clerodendrum trichotomum Thunb Xitong gel plasters Box-Behnken response surface method extraction process |
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