FAS/FASL基因单核苷酸多态与肿瘤易感性的关系研究进展

肿瘤坏死因子受体超家族6基因(TNFRSF6,又称FAS)及其配体(FASL)在细胞凋亡中具有重要的调节作用.FAS/FASL基因启动子区突变,会导致凋亡通道调节异常,可能促进肿瘤的发生.本文综述FAS/FASL基因单核苷酸多态(SNPs)的分布、功能及其与肿瘤易感性的关系,发现FAS-1377G等位基因在亚洲人群中分布频率低于欧美人群;FAS-670A等位基因在不同人群中的分布频率没有明显差异;而FASL-844C等位基因在不同人群中分布频率有一定差异但没有明显的地区规律性;FAS-1377G/A、FAS-670A/G和FAS-844T/C对不同人群、不同肿瘤易感性结果不一致.这些结果为不同人群和个体之间对肿瘤易感性不同提供了生物学依据.

Progress on the relationship between single nucleotide polymorphism of FAS/FASL gene and tumor susceptibility

Tumor necrosis factor receptor super family 6 gene ( TNFRSF6, namely FAS) and FAS ligand ( FASL) play a crucial role in apoptosis regulation. Single nucleotide polymorphism ( SNP) in the promoter region of FAS/FASL gene may produce abnormal apoptosis and then lead to tumorigenesis. This paper reviews the distribution, function and relationship with cancer risk of FAS/FASL gene SNPs, and finds that the distribution frequency of FAS-1377G allele in the Asian population is lower than the European and American populations and the frequency of the FAS-670A allele in different populations is not significantly different. There are some differences in the frequency of FASL-844C allele in different populations, but no obvious regional regularity. These three polymorphisms are not consistent with the susceptibility of different populations and different tumors. The current results may provide a biological theory for the different tumor susceptibility among different groups and individuals.