| 桑椹的化学成分研究 |
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| 引用本文： | 王宜海,易晓敏,梁立青,刘娟,何祥久. 桑椹的化学成分研究[J]. 广东药学院学报, 2017, 33(3). DOI: 10.16809/j.cnki.2096-3653.2017030803 |
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| 作者姓名： | 王宜海 易晓敏 梁立青 刘娟 何祥久 |
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| 作者单位： | 1. 广东药科大学 药学院,广东 广州 510006;武汉大学 药学院,湖北 武汉 430071;2. 广东药科大学 药学院,广东 广州,510006;3. 武汉大学 药学院,湖北 武汉,430071 |
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| 基金项目： | 国家自然科学基金项目，广东省中医药局面上科研项目 |
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| 摘 要： | 目的 研究桑椹的化学成分.方法 采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱、制备HPLC等色谱方法进行分离纯化,采用理化性质结合波谱数据解析鉴定化合物的结构.结果 从桑椹的70%(体积分数)乙醇提取物中分离得到7个化合物,分别鉴定为aurantiamide(1),细胞松弛素B(2),(22E)-24-methyl-5α-cholesta-7,22-diene-3β,5α,6β-triol(3),(22E)-5α,8α-epidioxyergosta-6,22-dien-3β-ol(4),7β-羟基谷甾醇(5),β-谷甾醇(6),胡萝卜苷(7).结论 化合物1~5为首次从桑椹中分离得到.
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| 关 键 词： | 桑椹 化学成分 结构鉴定 |
Study on chemical constituents from the berries of Morus alba L. |
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| WANG Yihai,YI Xiaomin,LIANG Liqing,LIU Juan,HE Xiangjiu. Study on chemical constituents from the berries of Morus alba L.[J]. Academic Journal of Guangdong College of Pharmacy, 2017, 33(3). DOI: 10.16809/j.cnki.2096-3653.2017030803 |
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| Authors: | WANG Yihai YI Xiaomin LIANG Liqing LIU Juan HE Xiangjiu |
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| Abstract: | Objective To investigate the chemical constituents from the berries of Morus alba L.Methods The compounds were isolated by chromatographies on silica gel column,ODS column,Sephadex LH-20 column,preparative HPLC and their chemical structures were elucidated on the basis of physicochemical properties and spectroscopic data.Results Seven compounds were isolated and their structures were identified to be aurantiamide (1),cytochalasin B (2),(22E)-24-methyl-5α-cholesta-7,22-diene-3β,5α,6β-triol(3),(22E)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (4),7β-hydroxy-sitosterol(5),β-sitosterol(6),and daucosterine(7).Conclusion Compounds 1-5 were isolated from the berries of Morus alba L.for the first time. |
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| Keywords: | Morus alba L. chemical constituents structural identification |
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