| 大鼠肾缺血再灌注过程中脂质过氧化损伤的实验研究 |
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| 引用本文： | 夏安周,邢淑华,张昭辉. 大鼠肾缺血再灌注过程中脂质过氧化损伤的实验研究[J]. 徐州医学院学报, 2004, 24(2): 109-111 |
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| 作者姓名： | 夏安周 邢淑华 张昭辉 |
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| 作者单位： | 1. 徐州医学院药理学教研室,江苏,徐州,221002
2. 中国人民解放军第九十七医院普外科,江苏,徐州,221004 |
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| 基金项目： | 江苏省高校自然科学基金资助项目 (310 14 4 ) |
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| 摘 要： | 目的 探讨急性肾缺血再灌注损伤的机制。方法 采用大鼠双侧肾蒂夹闭的肾缺血再灌注损伤模型，测定肾组织丙二醛(MDA)水平和超氧化物歧化酶(SOD)的活性，光镜下观察肾组织病理变化。结果 肾缺血再灌注后肾组织中MDA含量呈进行性增高，而单纯肾缺血MDA无明显变化；单纯肾缺血和缺血后再灌注肾组织中SOD活性呈进行性降低；缺血和再灌注组均有不同程度肾损害。结论 脂质过氧化参与肾缺血再灌注损伤。
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| 关 键 词： | 大鼠 肾缺血 再灌注损伤 脂质过氧化损伤 肾组织 SOD |
| 文章编号： | 1000-2065(2004)02-0109-03 |
The study on lipid peroxidation injury during renal ischemia/reperfusion in rats |
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| XIA An-zhou,XING Shu-hua,ZHANG Zhao-hui. The study on lipid peroxidation injury during renal ischemia/reperfusion in rats[J]. Acta Academiae Medicinae Xuzhou, 2004, 24(2): 109-111 |
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| Authors: | XIA An-zhou XING Shu-hua ZHANG Zhao-hui |
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| Abstract: | Objective To investigate lipid peroxidation injury during renal ischemic/reperfusion in rats. Methods Bilateral renal ischemia was induced by clamping the renal pedicles for 45 minutes. No reperfusion or 30 min and 24 h of reperfusion was allowed in separate groups. Malondialdehyde (MDA) levels and superoxide dismutase (SOD) activities were determined to assess lipid peroxidation. Pathologic changes were studied by optic microscopy. Results The renal content of MDA in ischemia/reperfusion groups was increased,but not significantly in the ischemic group. The activity of SOD in renal tissue decreased both in ischemic group and in ischemic/reperfusion groups. The renal histomorphological damages in ischemia/reperfusion groups were more serious than that in the simple ischemic group. Conclusion Lipid peroxidation is involved in renal ischemic/reperfusion injury. |
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| Keywords: | kidney ischemia/reperfusion injury lipid peroxidation |
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