Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB |
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Authors: | Sudhakar Selvaraj Naga Venkatesha Murthy Zubin Bhagwagar Subrata K. Bose Rainer Hinz Paul M. Grasby Philip J. Cowen |
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Affiliation: | 1. University Department of Psychiatry, Warneford Hospital, Oxford, UK 2. Medical Research Council Cyclotron Unit, Hammersmith Hospital, London, UK 3. GSK CIC, Imperial College London, London, UK 4. Department of Psychiatry, Yale University, Newhaven, USA 5. Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
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Abstract: | Background The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission and has been implicated in the pathophysiology of major depression. In a previous positron emission tomography study, we found no difference in brain 5-HTT binding between unmedicated recovered depressed patients and healthy controls. Aim This study aims to assess brain 5-HTT binding in a group of unmedicated acutely depressed patients in comparison to healthy controls. Methods We studied 5-HTT binding using [11C]DASB in conjunction with positron emission tomography in 12 medication-free depressed patients with a mean duration of illness of about 1?year and 24 healthy controls. Results The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex. Conclusions These results suggest that diminished availability of the 5-HTT in the brain may be a state marker of acute depression. Alternatively, low 5-HTT binding may delineate a group of depressed patients with a poor long-term prognosis. |
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