| Down-regulation of Cardiac Bradykinin B2 Receptors and eNOs mRNA in Rats with Remnant Kidneys |
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| 引用本文： | 万槐斌,涂玲,刘晓晴,邓娟娟. Down-regulation of Cardiac Bradykinin B2 Receptors and eNOs mRNA in Rats with Remnant Kidneys[J]. 华中科技大学学报(医学英德文版), 2005, 25(3): 276-278. DOI: 10.1007/BF02828141 |
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| 作者姓名： | 万槐斌 涂玲 刘晓晴 邓娟娟 |
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| 作者单位： | Geriatric Department，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Geriatric Department，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Geriatric Department，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Geriatric Department，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology Wuhan 430030，China，Wuhan 430030，China，Wuhan 430030，China，Wuhan 430030，China |
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| 摘 要： | Bradykinin,ani mportant substance in the de-velopment of cardiovascular diseases ,exerts its ac-tions through the activation of B1 or B2 receptors .B1 receptors are expressing mainly in pathologicalconditions and mediate inflammatory and pain-pro-ducing effects[1];B2 receptors(BKB2Rs) mediatemost of cardiovascular protective effects throughreleasing nitric oxide (NO) ,prostaglandins (PGs)and endothelium-derived hyperpolarizing factor(EDHF)[2]. The components for the generationand action …
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| 关 键 词： | 心脏血管缓激肽B2 mRNA eNOs 肾形矿脉 内生氧化酶 |
| 收稿时间： | 2005-02-28 |
Down-regulation of cardiac bradykinin B2 receptors and eNOs mRNA in rats with remnant kidneys |
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| Wan Huaibin,Tu Ling,Liu Xiaoqing,Deng Juanjuan. Down-regulation of cardiac bradykinin B2 receptors and eNOs mRNA in rats with remnant kidneys[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2005, 25(3): 276-278. DOI: 10.1007/BF02828141 |
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| Authors: | Wan Huaibin Tu Ling Liu Xiaoqing Deng Juanjuan |
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| Affiliation: | Geriatric Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | The changes in the expression of cardiac bradykinin B2 receptors (BKB2Rs) and endogenous nitrix oxide synthase (eNOs) mRNA were studied in rats with remnant kidneys. Thirty-two rats were divided into sham-operated and experimental groups randomly (n=16 in each group). The remnant kidney model was established by 2-stage 5/6 nephrectomy. Blood pressure and serum Cr were measured before operation and 15, 30, 60, 120 days after 5/6 nephrectomy. Eight animals in each group were killed at the first month and 4th month after the operation. The expression of BKB2Rs and eNOs mRNAs was detected by using RT-real time PCR from isolated left ventricle, and their correlation was also analyzed. The results showed that blood pressure and serum Cr were increased significantly 15 days after 5/6 nephrectomy (both P<0.01), and the hypertension and azomia existed constantly till 120 days but had no significant fluctuation. Cardiac BKB2Rs and eNOs mRNA was declined time-dependently (both P<0.05). And there was a close positive correlation between cardiac BKB2Rs and eNOs mRNA (r=0.82, P<0.01). It was suggested that a significant chronic renal failure can be produced at least 15 days after 5/6 nephrotomy and can sustain more than 4 months. The expression of BKB2Rs and eNOs was down-regulated time-dependently in this model, and there was a significant correlation between them. |
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| Keywords: | bradykinin B2 receptors endogenous nitric oxide synthase myocardium 5/6 nephretomy |
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