| 三氧化二砷联合羟基脲治疗慢性粒细胞白血病的效果及超声成像的改变 |
| |
| 引用本文： | 黄晓东.三氧化二砷联合羟基脲治疗慢性粒细胞白血病的效果及超声成像的改变[J].中国现代医生,2010,48(4):64-65,74. |
| |
| 作者姓名： | 黄晓东 |
| |
| 作者单位： | 广东惠州中心医院功能科,广东惠州,516001 |
| |
| 摘 要： | 目的探讨三氧化二砷（As2O3）联合羟基脲（HU）治疗慢性粒细胞白血病（CML）的效果及超声成像的改变。方法60例CML患者按治疗方法不同分为As2O3治疗组（A组）30例和As2O3联合HU治疗组（B组）30例，观察治疗前后疗效、外周血常规、肝脾声像学改变。结果两组治疗后红细胞、血小板低于治疗前（t=2．234，t=2．234，t=2．582，t=2．378，P均〈0．05）；A组缓解率（50．0％）、总有效率（86．6％）明显高于B组（36．6％）、（70．0％）（χ^2=3．98，χ^2=3．99，P〈0．05）；2组治疗后肝、脾较治疗前缩小（t=2．785，t=-2．845，t=2．578，t=2．599，P均〈0．05）；肝实质回声增强，呈密集细点状回声；脾呈中、重度肿大，脾实质、被膜回声增强，而且不光滑，可见混合性回声和低回声。结论As2O3联合HU治疗慢性粒细胞白血病有较好的疗效，不同时期超声影像的变化，有助于CML的诊断和治疗。
|
| 关 键 词： | 三氧化二砷 羟基脲 白血病 慢性粒细胞 治疗 超声 |
Arsenic Trioxide Combined with Hydroxyurea for Chronic Myeloid Leukemia and Effects of Ultrasound Imaging Changes |
| |
| Authors: | HUANG Xiaodong |
| |
| Institution: | HUANG Xiaodong Department of Function,Huizhou Central Hospital,Huizhou 516001,China |
| |
| Abstract: | Objective To investigate the curative efficacy of arsenic trioxide(As2O3) combined with hydroxyurea(HU) in the treatment of chronic myeloid leukemia and the effects of ultrasound imaging changes. Methods Sixty cases of chronic myeloid leukemia were divided into As2O3 treatment group(in Group A,30 cases) and As2O3 combined with HU treatment group(Group B,30 cases. The peripheral blood routine,curative effect and liver and spleen morphology before and after treatment were observed. Results The indexes of the ... |
| |
| Keywords: | Arsenic trioxide Hydroxyurea Leukemia Chronic myelogenous Treatment Ultrasound |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
