| 1-去氧-D-核糖的合成 |
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| 引用本文： | 赵桂森,刘永久,徐玉文. 1-去氧-D-核糖的合成[J]. 中国现代应用药学, 2002, 19(1): 47-48 |
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| 作者姓名： | 赵桂森 刘永久 徐玉文 |
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| 作者单位： | 济南,250012,山东大学药学院药化教研室 |
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| 摘 要： | 目的：化学合成1-去氧-D-核糖并进行工艺改进。方法：以D-核糖为原料，经甲基化，硅烷基化、还原裂争，水解反应制得1-去氧-D-核糖。结果：化学结构经^1HNMR,^13CNMR和DEPT^13CNMR确证。总收率72.5%。结论：该方法适合于合成1-去氧-D-核糖。
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| 关 键 词： | 1－去氧－D－核糖 D－核糖 合成 药物中间体 抗艾滋病毒药 中间体 |
| 修稿时间： | 2001-06-04 |
Synthesis of 1-deoxy-d-ribose |
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| Zhao Guisen(Zhao GS,Liu Yongjiu(Liu YJXu Yuwen(Xu YW. Synthesis of 1-deoxy-d-ribose[J]. The Chinese Journal of Modern Applied Pharmacy, 2002, 19(1): 47-48 |
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| Authors: | Zhao Guisen(Zhao GS Liu Yongjiu(Liu YJXu Yuwen(Xu YW |
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| Abstract: | OBJECTIVE: To synthesize 1 Deoxy D Ribose by improved method. METHOD: 1 Deoxy D ribose was prepared from D ribose via methylation, silylation, reductive cleavage and hydrolysis by a sequence of four high yield reactions. RESULT: The structure was determined by 1HNMR, 13 CNMR and DEPT 13 CNMR. The total yield was 72.5%. CONCLUSION: This method was developed for large scale synthesis. |
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| Keywords: | Deoxy D ribose D ribose synthesis |
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