| 表鬼臼毒素羧酸酯的合成及体外抗肿瘤活性 |
| |
| 引用本文： | 潘建林,王彦广,陈耀祖. 表鬼臼毒素羧酸酯的合成及体外抗肿瘤活性[J]. 药学学报, 1997, 32(12): 898-901 |
| |
| 作者姓名： | 潘建林 王彦广 陈耀祖 |
| |
| 作者单位： | 兰州大学应用有机化学国家重点实验室，浙江大学化学系 |
| |
| 摘 要： | 在三氟化硼·乙醚的催化作用下,鬼臼毒素(I)与有机酸直接脱水生成了具有4β-构型的表鬼臼毒素羧酸酯(IIa～g),所有合成产物经IR,1HNMR,MS和元素分析等确证其结构,初步药理试验表明,该类化合物对小鼠白血病P388、人胃癌SGC-7901有一定的抑制活性。
|
| 关 键 词： | 鬼臼毒素 表鬼臼毒素羧酸酯 抗肿瘤 |
Synthesis of epipodophyllotoxin carboxylates and antitumor activity in vitro] |
| |
| JL Pan,YG Wang and YZ Chen. Synthesis of epipodophyllotoxin carboxylates and antitumor activity in vitro][J]. Acta pharmaceutica Sinica, 1997, 32(12): 898-901 |
| |
| Authors: | JL Pan YG Wang YZ Chen |
| |
| Affiliation: | Department of Chemistry, Zhejiang University, Hangzhou 310027. |
| |
| Abstract: | A series of epipodophyllotoxin carboxylates were prepared from podophyllotoxin by reacting with organic acids under the catalysis of BF3.Et2O. All these products were characterized through IR, 1HNMR, MS and elemental analysis. These compounds showed significant antitumor activities against mouse leukemia P388 and human stomach cancer SGC-7901 in pharmacological tests in vitro. |
| |
| Keywords: | Podophyllotoxin Epipodophyllotoxin carboxylate Antitumor activity |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
