RECK Expression in the Rat Ventral Prostate: Response to Castration Involves a Balance Between Epithelial and Stromal Expression |
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| Authors: | Helene Peters Taize Machado Augusto Alexandre Bruni‐cardoso Hernandes F Carvalho |
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| Affiliation: | Department of Anatomy, Cell Biology, Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), Campinas SP, Brazil |
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| Abstract: | RECK is expressed in the rat ventral prostate. The amount of mRNA increased after castration. In situ hybridization and immunohistochemistry demonstrated a transition from epithelial to stromal expression. This demonstrates that stromal cells upregulate RECK expression to regulate matrix metalloproteinases activity responsible for extracellular matrix (ECM) changes occurring after castration. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc. |
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| Keywords: | castration prostate in situ hybridization RECK |
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