Design and Synthesis of Novel Pyrazino[2,1‐a]isoquinolin Derivatives with Potent Antifungal Activity |
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| Authors: | Hui Tang Can‐hui Zheng Ju Zhu Bing‐yue Fu You‐jun Zhou Jia‐guo Lv |
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| Affiliation: | 1. School of Pharmacy, Second Military Medical University, Shanghai, P. 2. R. China. Fax: +86 21 818‐7123‐1 |
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| Abstract: | A series of novel pyrazino[2,1‐a]isoquinolin compounds were designed, synthesized, and their antifungal activities in vitro were evaluated. The results showed that all of the title compounds exhibited antifungal activities. Most of them exhibited stronger antifungal activities than the lead compounds; compound 7c is more potent than fluconazole against two of the three tested fungal strains. The studies presented here provide a new structural type for the development of novel antifungal agents. |
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| Keywords: | Antifungal Lanosterol 14α ‐demethylase Pyrazino[2,1‐a]isoquinolin Synthesis |
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