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Synthesis and in‐vitro Cytotoxic Evaluation of Novel Pyridazin‐4‐one Derivatives |
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| Authors: | Souad Mojahidi El Mostapha Rakib Hanan Sekkak Said Abouricha Nouredine Benchat Hassan Ait Mousse Abdelmajid Zyad |
| Affiliation: | 1. Laboratory of Organic and Analytical Chemistry, Faculty of Sciences and Technology, Béni‐Mellal, Morocco. Fax: +212 5 234‐85201;2. Department of Chemistry, Faculty of Sciences, Oujda, Morocco;3. Laboratory of Biological Engineering, Faculty of Sciences and Technology, Béni‐Mellal, Morocco |
| Abstract: | A new series of N‐aryl‐4‐oxo‐1,4‐dihydro‐pyridazine‐3‐carboxylic acids has been synthesized by condensation of aryldiazonium with 4‐hydroxy‐6‐methyl‐2‐pyrone. Some of these compounds exhibited in‐vitro cytotoxic activity with moderate to excellent growth inhibition against the murine P815 mastocytoma cell line. Compound 5b showed an important cytotoxic activity against cell line P815 (IC50 = 0.40 μg/mL). |
| Keywords: | Arylhydrazonopyranedione Cytotoxic activity Pyrazolo[4,3‐c]pyridazinone Pyridazinone 2‐Pyrone |