Quantitative Assessment of Skin Stiffness Using Ultrasound Shear Wave Elastography in Systemic Sclerosis

This study was aimed at investigating the performance of ultrasound shear wave elastography (US-SWE) in the assessment of skin (the dermis) stiffness in patients with systemic sclerosis (SSc). The thickness and elastic modulus of the skin were measured using US-SWE at 6 sites in 60 SSc patients and 60 healthy volunteers: the bilateral middle fingers and forearms and the anterior chest and abdomen. To evaluate clinical scores, the measurements were also extended to 17 skin sites in 30 patients. The diagnostic performance of US-SWE in the differentiation of SSc from healthy skin was determined by receiver operating characteristic (ROC) curve analysis, and the reliability of the measurement was evaluated with intra- and inter-class correlation coefficients. The results of US-SWE were compared with modified Rodnan skin thickness scores. Our results indicated that (i) the elastic modulus values were significantly higher in SSc patients than in controls, with or without normalization by skin thickness; (ii) receiver operating characteristic analysis revealed normalized US-SWE cutoff values with a very high accuracy for right and left fingers (areas under the curve?=?0.974 and 0.949), followed by left forearm (0.841), anterior abdomen (0.797), right forearm (0.772) and anterior chest (0.726); (iii) the reliability of US-SWE measurements was good for all examined sites with intra-observer correlation coefficients of 0.845–0.996 and inter-observer correlation coefficients of 0.824–0.985; and (iv) total scores of skin involvement determined at 17 sites (modified Rodnan skin thickness scores) correlated with skin stiffness (r?=?0.832) and thickness (r?=?0.736). In conclusion, US-SWE is a quantitative method with high specificity, sensitivity and reliability in the detection of SSc involvement. This non-invasive, real-time and operator-independent imaging technique could be an ideal tool for the assessment of SSc disease.