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Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs |
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| Authors: | K. Alexander S. Authier J. R. E. del Castillo V. Arora S. Qi M. Guillot G. Beauchamp E. Troncy |
| Affiliation: | 1. Faculté de médecine vétérinaire, Université de Montréal, PO Box 5000, St‐Hyacinthe, Quebec, J2S 7C6, Canada;2. GREPAQ, Department of Veterinary Biomedicine, Université de Montréal, PO Box 5000, St‐Hyacinthe, Quebec, J2S 7C6, Canada;3. LAB Research Inc., 445 Armand Frappier, Laval, Quebec, H7V 4B3, Canada;4. Research and Development, Talecris Biotherapeutics, Research Triangle Park, NC, USA;5. Department of Surgery, H?pital Notre‐Dame, Université de Montréal, Canada |
| Abstract: | Glomerular filtration rate (GFR) can be determined using Patlak plot analysis with single‐slice dynamic computed tomography (CT). Acute autologous graft failure has several causes, all of which induce a measurable decrease in glomerular filtration rate. This study demonstrated in an experimental model of canine autologous renal transplant that CT‐derived renal plasma clearance was significantly lower (p = 0.002) in dogs having undergone transplant (0.077 ± 0.058 ml min?1 ml renal tissue?1) compared with control dogs (0.396 ± 0.139 ml min?1 ml renal tissue?1). A significant negative curvilinear relationship was seen between serum creatinine and total renal plasma clearance (R2 = 0.84, p = 0.0001). Alterations in renal time attenuation curve shape in dogs having undergone transplant may have been related to increased renal vascular resistance related to tubular necrosis. CT‐GFR may be a useful experimental tool in the evaluation of renal dysfunction in transplant models. Copyright © 2010 John Wiley & Sons, Ltd. |
| Keywords: | computed tomography renal plasma clearance iodinated contrast media dogs transplantation kidney |