次声作用后大鼠脑中热休克蛋白70的表达和分布

观察次声作用后大鼠脑中热休克蛋白ＨＳＰ７０的表达和分布。方法：ＳＤ大鼠接受频率为８Ｈｚ和１６Ｈｚ，声压为９０ｄＢ和１２０ｄＢ次分别作用１，３，７，１４，２１ｄ后，采用免疫组织化学方法观察大鼠脑中ＨＳＰ７０的表达和分布。结果：各参数次声作一定时间后，ＨＳＰ７０阳性神经元主要布在下丘脑，边缘系统，听觉中枢，皮质，海马等脑区，各脑区出现阳性反应的时间不同，且随次声频率增高、声压增强及作用次数增加，ＨＳＰ

Expression and distribution of heat shock protein70 in the brain of the rat exposed to infrasound

Aim: To explore the expression and distributionof HSP70 in the brain of rat exposed to infrasound.Methods: Rats were exposed to infrasound of & Hi and 16 Hzwith the intensity of 90 dB and 120 dB for 1, 3, 7, 14, 21days. Then immunohistochemical technique was employedto detect the expression and distribution of HSP70. Results:HSP70 immunoreactive neurous presented mainly inhypothalamus, lmbic system, central auditory pathways,cortex and hippocampus after exposed for certain times. Thetime that a certain region begain to react differented fromeach other. The number of the HSP70 immunoreactiveneurons grew as the increasing of the frequency, intensity andtime of action. Conclusion: These regions are sensitive toinfrasound and the effects of infrasound on brain are closelyrelated to the parameters.