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慢性干咳伴有气道高反应性即是咳嗽变异性哮喘吗?
引用本文:辛建保,向敏,陶晓南.慢性干咳伴有气道高反应性即是咳嗽变异性哮喘吗?[J].中华结核和呼吸杂志,1998,21(3):138-140.
作者姓名:辛建保  向敏  陶晓南
作者单位:同济医科大学协和医院呼吸内科
摘    要:目的评价气道反应性测定在咳嗽变异性哮喘(CVA)诊断中的价值。方法124例慢性干咳患者经气道反应性测定后,分为咳嗽气道高反应阳性组(CBH-P组)35例,咳嗽气道高反应阴性组(CBH-N组)33例。观察常规肺功能、抗原皮肤点刺试验阳性率、血嗜酸性粒细胞计数、血IgE水平、泼尼松试验阳性率并随访2年后发展成典型哮喘例数。结果35例CBH-P组一秒钟用力呼气容积占用力肺活量比值(FEV1%)为74±10(P<0.01),33例CBH-N组为83±10(P<0.05)。抗原皮肤点刺试验阳性率CBH-P组为51%,CBH-N组为12%;血嗜酸性粒细胞计数CBH-P组为0.5±0.1×109/L,CBH-N组为0.3±0.1×109/L;泼尼松试验阳性率CBH-P组为83%,CBH-N组为15%。随访2年后发展成典型哮喘例数中CBH-P组有16例发展成典型哮喘。在CBH-P组中发展成典型哮喘与未发展成典型哮喘患者在皮肤抗原点刺试验阳性率、常规肺功能、反应阈值(Dmin)及致喘阈值(Dcw/Dmin)等方面差异均无显著性。结论气道反应性测定是诊断CVA的重要依据,但不是唯一的诊断标准,还应结合其它临床资料综合判断

关 键 词:咳嗽  哮喘  气道反应性

Will chronic nonproductive cough with bronchial hyperresponsiveness be cough variant asthma?
Xin Jianbao,Xiang Min,Tao Xiaonan,et al..Will chronic nonproductive cough with bronchial hyperresponsiveness be cough variant asthma?[J].Chinese Journal of Tuberculosis and Respiratory Diseases,1998,21(3):138-140.
Authors:Xin Jianbao  Xiang Min  Tao Xiaonan  
Institution:Department of Respiratory Diseases, Union Hospital, Tongji Medical University, Wuhan, 430022.
Abstract:Objective The clinical characteristics of the patients suffered from chronic nonproductive cough with bronchial hyperresponsiveness were analyzed, so as to evaluate the value of measurement of bronchial responsiveness in diagnosis of cough variant asthma (CVA). Method 124 patients with chronic nonproductive cough were divided into two groups after the measurement of bronchial responsiveness: cough bronchial hyperresponsiveness positive group (CBH P, n =35) and cough bronchial hyperresponsiveness negative group (CBH N, n =33). Routine pulmonary function, positive rate of antigen skin pitting lest, count of blood eosinophil cells, level of blood IgE, positive rate of prednisone test and the number of development of classical asthma in two year following up were studied. Result The percentage of FEV1.0 in group CBH P was significantly lower than in group CBH N, but antigen skin pitting test, count of blood eosinophil cells, prednisone test and the number of development of classic asthma in two year following up were all higher than in the latter group. In group CBH P, there was no significant difference in positive rate of antigen skin pitting test, routine pulmonary function, reacting threshold(Dmin) and wheezing threshold (DCW/Dmin) between the patients who developed classic asthma and those who did not. Conclusion The measurement of bronchial responsiveness is important for the diagnosis of CVA, but it is not the only diagnostic criteria and should be combined with other clinical data.
Keywords:Cough    Asthma    Bronchial responsiveness  
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